HCSGD entry for WDR5

1. General information

Official gene symbolWDR5
Entrez ID11091
Gene full nameWD repeat domain 5
Other gene symbolsBIG-3 SWD3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000123Histone acetyltransferase complexIDAcellular_component
GO:0001501Skeletal system developmentIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005671Ada2/Gcn5/Ada3 transcription activator complexIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0018022Peptidyl-lysine methylationIDAbiological_process
GO:0035097Histone methyltransferase complexIDAcellular_component
GO:0042800Histone methyltransferase activity (H3-K4 specific)IDAmolecular_function
GO:0043966Histone H3 acetylationIDAbiological_process
GO:0043981Histone H4-K5 acetylationIDAbiological_process
GO:0043982Histone H4-K8 acetylationIDAbiological_process
GO:0043984Histone H4-K16 acetylationIDAbiological_process
GO:0043995Histone acetyltransferase activity (H4-K5 specific)IDAmolecular_function
GO:0043996Histone acetyltransferase activity (H4-K8 specific)IDAmolecular_function
GO:0046972Histone acetyltransferase activity (H4-K16 specific)IDAmolecular_function
GO:0048188Set1C/COMPASS complexIDAcellular_component
GO:0051568Histone H3-K4 methylationIDAbiological_process
GO:0071339MLL1 complexIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85524848980.24556345880.99999024730.9537370223

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0701642947
GSE13712_SHEARUp0.2497589261
GSE13712_STATICUp0.2689124569
GSE19018Down-0.2780340901
GSE19899_A1Down-0.1732860477
GSE19899_A2Up0.2372716988
PubMed_21979375_A1Up0.1273181332
PubMed_21979375_A2Down-0.0444506470
GSE35957Down-0.4385537913
GSE36640Down-1.0649407412
GSE54402Up0.0862939822
GSE9593Down-0.2721032662
GSE43922Up0.1062820964
GSE24585Down-0.0512876956
GSE37065Down-0.1941184764
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.0347600508

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT039870CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042008CLASHFunctional MTI (Weak)23622248
hsa-miR-30c-5pMIMAT0000244MIRT047941CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.