HCSGD entry for AKR1C4

1. General information

Official gene symbolAKR1C4
Entrez ID1109
Gene full namealdo-keto reductase family 1, member C4
Other gene symbols3-alpha-HSD C11 CDR CHDR DD-4 DD4 HAKRA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0001758Retinal dehydrogenase activityIDAmolecular_function
GO:0004033Aldo-keto reductase (NADP) activityTASmolecular_function
GO:0005737CytoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006699Bile acid biosynthetic processTASbiological_process
GO:0006869Lipid transportTASbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0008206Bile acid metabolic processTASbiological_process
GO:0008209Androgen metabolic processTASbiological_process
GO:0009055Electron carrier activityTASmolecular_function
GO:0015125Bile acid transmembrane transporter activityTASmolecular_function
GO:0015721Bile acid and bile salt transportTASbiological_process
GO:0016655Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorIDAmolecular_function
GO:0034220Ion transmembrane transportTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0044597Daunorubicin metabolic processIMPbiological_process
GO:0044598Doxorubicin metabolic processIMPbiological_process
GO:0047023Androsterone dehydrogenase activityIDAmolecular_function
GO:0047743Chlordecone reductase activityIEAmolecular_function
GO:0055085Transmembrane transportTASbiological_process
GO:0071395Cellular response to jasmonic acid stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22147959040.86040474910.90307299471.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2770760997
GSE13712_SHEARUp0.2016294033
GSE13712_STATICDown-0.1912291256
GSE19018Up0.0504114220
GSE19899_A1Up0.1176196850
GSE19899_A2Down-0.2197064354
PubMed_21979375_A1Down-0.1858990505
PubMed_21979375_A2Up0.2633434049
GSE35957Down-0.1485091916
GSE36640Down-0.0153524079
GSE54402Up0.1472950385
GSE9593Up0.3834847734
GSE43922Up0.0188345398
GSE24585Up0.4008419416
GSE37065Up0.2403617134
GSE28863_A1Up0.0468790797
GSE28863_A2Up0.1777786046
GSE28863_A3Up0.1599103225
GSE28863_A4Down-0.2217352259
GSE48662Down-0.0776893157

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.