HCSGD entry for CHD4
1. General information
| Official gene symbol | CHD4 |
|---|---|
| Entrez ID | 1108 |
| Gene full name | chromodomain helicase DNA binding protein 4 |
| Other gene symbols | Mi-2b Mi2-BETA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IPI | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0008134 | Transcription factor binding | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0016581 | NuRD complex | IDA IEA | cellular_component |
| GO:0016818 | Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | IEA | molecular_function |
| GO:0032508 | DNA duplex unwinding | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0456442916 | 0.5403152350 | 0.4742737298 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1061207764 |
| GSE13712_SHEAR | Down | -0.3165233614 |
| GSE13712_STATIC | Down | -0.1892838470 |
| GSE19018 | Down | -0.0049015770 |
| GSE19899_A1 | Up | 0.3036845310 |
| GSE19899_A2 | Down | -0.1909840725 |
| PubMed_21979375_A1 | Up | 0.1128417164 |
| PubMed_21979375_A2 | Up | 0.5880843955 |
| GSE35957 | Down | -0.4299907406 |
| GSE36640 | Down | -0.6311132733 |
| GSE54402 | Up | 0.1938395099 |
| GSE9593 | Down | -0.1769551763 |
| GSE43922 | Up | 0.3198027033 |
| GSE24585 | Up | 0.0570927260 |
| GSE37065 | Down | -0.0863232604 |
| GSE28863_A1 | Up | 1.6367645786 |
| GSE28863_A2 | Up | 1.4945449071 |
| GSE28863_A3 | Down | -0.2191772559 |
| GSE28863_A4 | Up | 0.1613640477 |
| GSE48662 | Up | 0.1177222303 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-491-5p | MIMAT0002807 | MIRT004656 | Luciferase reporter assay | Non-Functional MTI | 20065103 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016455 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016455 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027771 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032436 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032436 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036982 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039684 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041696 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048143 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050859 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT051330 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
