HCSGD entry for TOPBP1
1. General information
| Official gene symbol | TOPBP1 |
|---|---|
| Entrez ID | 11073 |
| Gene full name | topoisomerase (DNA) II binding protein 1 |
| Other gene symbols | TOP2BP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000794 | Condensed nuclear chromosome | IEA | cellular_component |
| GO:0000922 | Spindle pole | IEA | cellular_component |
| GO:0001673 | Male germ cell nucleus | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005694 | Chromosome | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0006259 | DNA metabolic process | TAS | biological_process |
| GO:0006281 | DNA repair | NAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0008022 | Protein C-terminus binding | TAS | molecular_function |
| GO:0010212 | Response to ionizing radiation | IDA | biological_process |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9775431898 | 0.0042203260 | 0.9999902473 | 0.1322411415 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1069522464 |
| GSE13712_SHEAR | Down | -0.3651183254 |
| GSE13712_STATIC | Down | -0.2819186778 |
| GSE19018 | Down | -0.3128164705 |
| GSE19899_A1 | Down | -0.8192033466 |
| GSE19899_A2 | Down | -1.1937561609 |
| PubMed_21979375_A1 | Down | -0.4019199925 |
| PubMed_21979375_A2 | Down | -1.0885457874 |
| GSE35957 | Down | -0.7755419962 |
| GSE36640 | Down | -2.0171182034 |
| GSE54402 | Down | -0.2385184776 |
| GSE9593 | Down | -0.7344132551 |
| GSE43922 | Down | -0.3623307593 |
| GSE24585 | Up | 0.0438929155 |
| GSE37065 | Down | -0.0846124849 |
| GSE28863_A1 | Up | 0.2732101199 |
| GSE28863_A2 | Up | 0.9175323034 |
| GSE28863_A3 | Down | -0.2951900862 |
| GSE28863_A4 | Down | -0.2367594438 |
| GSE48662 | Down | -0.1852222159 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022523 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024830 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026324 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23950734 | An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence |
| 23950734 | In metazoans, only TopBP1 has been identified as a direct ATR activator |
| 23950734 | The physiological function of the TopBP1 AAD is, however, unknown |
| 23950734 | To analyse TopBP1-W1147R cellular function in vivo, we silenced the wild type TopBP1 allele in heterozygous MEFs |
| 23950734 | We also show enforced TopBP1 dimerization promotes ATR-dependent Chk1 phosphorylation |
| 21149450 | TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells |
| 21149450 | TopBP1 plays important roles in chromosome replication, DNA damage response, and other cellular regulatory functions in vertebrates |
| 21149450 | Although the roles of TopBP1 have been studied mostly in cancer cell lines, its physiological function remains unclear in mice and untransformed cells |
| 21149450 | We generated conditional knock-out mice in which exons 5 and 6 of the TopBP1 gene are flanked by loxP sequences |
| 21149450 | This finding indicated that TopBP1 is essential for cell proliferation during early embryogenesis |
| 21149450 | Ablation of TopBP1 in TopBP1(flox/flox) mouse embryonic fibroblasts and 3T3 cells using Cre recombinase-expressing retrovirus arrests cell cycle progression at the G(1), S, and G(2)/M phases |
| 21149450 | Therefore, TopBP1 deficiency in untransformed mouse and human primary cells induces cellular senescence rather than apoptosis |
| 21149450 | These results indicate that TopBP1 is essential for cell proliferation and maintenance of chromosomal integrity |
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