HCSGD entry for CHD3
1. General information
| Official gene symbol | CHD3 |
|---|---|
| Entrez ID | 1107 |
| Gene full name | chromodomain helicase DNA binding protein 3 |
| Other gene symbols | Mi-2a Mi2-ALPHA ZFH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | TAS | molecular_function |
| GO:0004386 | Helicase activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA NAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0006333 | Chromatin assembly or disassembly | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA NAS | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007051 | Spindle organization | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IEA NAS | molecular_function |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0016581 | NuRD complex | IDA | cellular_component |
| GO:0016818 | Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | IEA | molecular_function |
| GO:0032508 | DNA duplex unwinding | TAS | biological_process |
| GO:0045111 | Intermediate filament cytoskeleton | IDA | cellular_component |
| GO:0051297 | Centrosome organization | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3312504122 | 0.0141354242 | 0.9999902473 | 0.2336706767 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2391608469 |
| GSE13712_SHEAR | Down | -0.5904221740 |
| GSE13712_STATIC | Down | -0.7409015585 |
| GSE19018 | Up | 0.0365613444 |
| GSE19899_A1 | Down | -0.3568028460 |
| GSE19899_A2 | Down | -0.8214351264 |
| PubMed_21979375_A1 | Down | -2.0328549388 |
| PubMed_21979375_A2 | Down | -0.4044302195 |
| GSE35957 | Down | -0.3389035459 |
| GSE36640 | Down | -0.3477649523 |
| GSE54402 | Down | -0.5990235850 |
| GSE9593 | Down | -0.2250204550 |
| GSE43922 | Down | -0.7583967443 |
| GSE24585 | Up | 0.5177765352 |
| GSE37065 | Down | -0.3146061121 |
| GSE28863_A1 | Up | 0.9763982669 |
| GSE28863_A2 | Up | 0.5328408103 |
| GSE28863_A3 | Up | 0.6872243677 |
| GSE28863_A4 | Up | 0.1081046791 |
| GSE48662 | Up | 0.1474027343 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032350 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032350 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036072 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036514 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051081 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
