HCSGD entry for UBE2C

1. General information

Official gene symbolUBE2C
Entrez ID11065
Gene full nameubiquitin-conjugating enzyme E2C
Other gene symbolsUBCH10 dJ447F3.2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleTASbiological_process
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005680Anaphase-promoting complexIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006511Ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0007049Cell cycleNASbiological_process
GO:0007051Spindle organizationNASbiological_process
GO:0007094Mitotic spindle assembly checkpointTASbiological_process
GO:0008054Cyclin catabolic processIDAbiological_process
GO:0010458Exit from mitosisIMPbiological_process
GO:0010994Free ubiquitin chain polymerizationIDAbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processIDA TASbiological_process
GO:0031536Positive regulation of exit from mitosisIMPbiological_process
GO:0048015Phosphatidylinositol-mediated signalingNASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051488Activation of anaphase-promoting complex activityTASbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
GO:0070979Protein K11-linked ubiquitinationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99059939210.00000691840.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-2.3297404892
GSE13712_SHEARDown-0.4982672639
GSE13712_STATICDown-0.7597416864
GSE19018Down-0.1452103584
GSE19899_A1Down-3.5603074071
GSE19899_A2Down-4.6072573536
PubMed_21979375_A1Down-2.9224669413
PubMed_21979375_A2Down-6.3357185875
GSE35957Down-5.0384348149
GSE36640Down-5.6422501817
GSE54402Down-1.3555028860
GSE9593Down-1.8300567009
GSE43922Down-0.9854339558
GSE24585Down-0.3359631591
GSE37065Down-0.1300310642
GSE28863_A1Down-0.4114644055
GSE28863_A2Up0.4928928000
GSE28863_A3Down-0.0851850016
GSE28863_A4Up0.3155897823
GSE48662Down-2.3985230563

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016310MicroarrayFunctional MTI (Weak)20304954
hsa-miR-140-3pMIMAT0004597MIRT021680SequencingFunctional MTI (Weak)20371350
hsa-miR-24-3pMIMAT0000080MIRT030369MicroarrayFunctional MTI (Weak)19748357
hsa-miR-16-5pMIMAT0000069MIRT031394ProteomicsFunctional MTI (Weak)18668040
hsa-miR-671-5pMIMAT0003880MIRT039262CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040327CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048197CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050549CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050874CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.