HCSGD entry for PAPD7
1. General information
| Official gene symbol | PAPD7 |
|---|---|
| Entrez ID | 11044 |
| Gene full name | PAP associated domain containing 7 |
| Other gene symbols | LAK-1 LAK1 POLK POLS TRF4 TRF4-1 TRF41 TUTASE5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA | molecular_function |
| GO:0004652 | Polynucleotide adenylyltransferase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006302 | Double-strand break repair | NAS | biological_process |
| GO:0007062 | Sister chromatid cohesion | TAS | biological_process |
| GO:0007076 | Mitotic chromosome condensation | NAS | biological_process |
| GO:0042493 | Response to drug | IDA | biological_process |
| GO:0043221 | SMC family protein binding | TAS | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8752892063 | 0.0196212682 | 0.9999902473 | 0.2729747491 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3998723683 |
| GSE13712_SHEAR | Down | -0.1361731711 |
| GSE13712_STATIC | Down | -0.2754767728 |
| GSE19018 | Down | -0.7897827784 |
| GSE19899_A1 | Down | -0.6024417459 |
| GSE19899_A2 | Down | -0.4527619881 |
| PubMed_21979375_A1 | Down | -0.0117625789 |
| PubMed_21979375_A2 | Down | -0.3218208097 |
| GSE35957 | Down | -0.6573789802 |
| GSE36640 | Down | -1.0630080185 |
| GSE54402 | Up | 0.4591390402 |
| GSE9593 | Down | -0.3569350895 |
| GSE43922 | Up | 0.0899342455 |
| GSE24585 | Down | -0.0076834400 |
| GSE37065 | Up | 0.1813331279 |
| GSE28863_A1 | Up | 0.3679721477 |
| GSE28863_A2 | Up | 0.6187921286 |
| GSE28863_A3 | Down | -0.1022683581 |
| GSE28863_A4 | Down | -0.2049120053 |
| GSE48662 | Down | -0.6113922946 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-423-3p | MIMAT0001340 | MIRT016682 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024572 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026248 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028280 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038569 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048855 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20542140 | In order to achieve this goal, DNA polymerases (Pols) have to faithfully execute DNA synthesis during chromosome replication and repair |
| 20542140 | However, the conditions under which Pols synthesize DNA are not always optimal; the template DNA can be damaged by various endogenous and exogenous genotoxic agents including reactive oxygen species (ROS), and ROS oxidize dNTPs in the nucleotide pool from which Pols elongate DNA strands |
| 20542140 | Both damaged DNA and oxidized dNTPs interfere with faithful DNA synthesis by Pols, inducing various cellular abnormalities, such as mutations, cancer, neurological diseases, and cellular senescence |
| 20542140 | In this review, we focus on the process by which Pols incorporate oxidized dNTPs into DNA and compare the properties of Pols: efficiency, i |
| 20542140 | In general, Pols involved in chromosome replication, the A- and B-family Pols, are resistant to the incorporation of 8-oxo-dGTP, whereas Pols involved in repair and/or translesion synthesis, the X- and Y-family Pols, incorporate nucleotides in a relatively efficient manner and tend to incorporate it opposite template dA rather than template dC, though there are several exceptions |
| 20542140 | We discuss the molecular mechanisms by which Pols exhibit different template base preferences for the incorporation of 8-oxo-dGTP and how Pols are involved in the induction of mutations via the incorporation of oxidized nucleotides under oxidative stress |
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