HCSGD entry for DSTN
1. General information
| Official gene symbol | DSTN |
|---|---|
| Entrez ID | 11034 |
| Gene full name | destrin (actin depolymerizing factor) |
| Other gene symbols | ACTDP ADF bA462D18.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0006928 | Cellular component movement | IEA | biological_process |
| GO:0008154 | Actin polymerization or depolymerization | TAS | biological_process |
| GO:0015629 | Actin cytoskeleton | IEA TAS | cellular_component |
| GO:0030042 | Actin filament depolymerization | IEA | biological_process |
| GO:0030836 | Positive regulation of actin filament depolymerization | IEA | biological_process |
| GO:0030864 | Cortical actin cytoskeleton | IEA | cellular_component |
| GO:0051014 | Actin filament severing | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8145964249 | 0.0846008890 | 0.9999902473 | 0.5523307711 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1880096074 |
| GSE13712_SHEAR | Down | -0.2107585502 |
| GSE13712_STATIC | Down | -0.1169067922 |
| GSE19018 | Down | -0.1231408738 |
| GSE19899_A1 | Down | -0.0746401162 |
| GSE19899_A2 | Down | -0.2872277945 |
| PubMed_21979375_A1 | Down | -0.6668819253 |
| PubMed_21979375_A2 | Down | -0.3763230977 |
| GSE35957 | Up | 0.2750609794 |
| GSE36640 | Up | 0.5188768049 |
| GSE54402 | Down | -0.1296422241 |
| GSE9593 | Up | 0.2516869613 |
| GSE43922 | Down | -0.0384041318 |
| GSE24585 | Down | -0.3808931255 |
| GSE37065 | Down | -0.3082884923 |
| GSE28863_A1 | Up | 0.2585012645 |
| GSE28863_A2 | Down | -0.3750879110 |
| GSE28863_A3 | Up | 0.3679290407 |
| GSE28863_A4 | Up | 0.1253928161 |
| GSE48662 | Down | -0.0202876195 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Lauryl Dimethylamine-N-Oxide | DB04147 | EXPT02013 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT041745 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22370639 | The tumor-suppressive effect of ZNF331 is mediated at least by downregulation of genes involved in cell growth promotion (DSTN, EIF5A, GARS, DDX5, STAM, UQCRFS1 and SET) and migration/invasion (DSTN and ACTR3), and upregulation of genome-stability gene (SSBP1) and cellular senescence gene (PNPT1) |
| 22370639 | A novel target of ZNF331 (DSTN) was functionally validated |
| 22370639 | Overexpression of DSTN in BGC-823 cells increased colony formation and migration ability |
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