HCSGD entry for KIF2C
1. General information
| Official gene symbol | KIF2C |
|---|---|
| Entrez ID | 11004 |
| Gene full name | kinesin family member 2C |
| Other gene symbols | KNSL6 MCAK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000775 | Chromosome, centromeric region | IDA IEA | cellular_component |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IEA | cellular_component |
| GO:0003777 | Microtubule motor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005871 | Kinesin complex | IEA | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0005881 | Cytoplasmic microtubule | ISS | cellular_component |
| GO:0007018 | Microtubule-based movement | IEA TAS | biological_process |
| GO:0007019 | Microtubule depolymerization | IDA IMP | biological_process |
| GO:0007059 | Chromosome segregation | IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008017 | Microtubule binding | IEA | molecular_function |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0019237 | Centromeric DNA binding | TAS | molecular_function |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0030951 | Establishment or maintenance of microtubule cytoskeleton polarity | IMP | biological_process |
| GO:0035371 | Microtubule plus-end | IDA | cellular_component |
| GO:0051010 | Microtubule plus-end binding | IDA | molecular_function |
| GO:0051983 | Regulation of chromosome segregation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9379916417 | 0.0000208693 | 0.9999902473 | 0.0084212121 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7651366363 |
| GSE13712_SHEAR | Down | -0.7351012416 |
| GSE13712_STATIC | Down | -0.7944898138 |
| GSE19018 | Up | 0.2251515036 |
| GSE19899_A1 | Down | -0.8488538956 |
| GSE19899_A2 | Down | -4.9702633476 |
| PubMed_21979375_A1 | Down | -2.0149751681 |
| PubMed_21979375_A2 | Down | -5.2723176411 |
| GSE35957 | Down | -3.3373282354 |
| GSE36640 | Down | -4.3117989180 |
| GSE54402 | Down | -0.8106160105 |
| GSE9593 | Down | -1.5773317596 |
| GSE43922 | Down | -2.1233040183 |
| GSE24585 | Up | 0.4723922737 |
| GSE37065 | Down | -0.4642221950 |
| GSE28863_A1 | Down | -0.1522749401 |
| GSE28863_A2 | Up | 0.7686267624 |
| GSE28863_A3 | Down | -0.0695955267 |
| GSE28863_A4 | Up | 0.0756215266 |
| GSE48662 | Down | -2.4642322919 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Phosphoaminophosphonic Acid-Adenylate Ester | DB04395 | EXPT00524 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-423-3p | MIMAT0001340 | MIRT016679 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019473 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023058 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT024025 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025335 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027317 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031974 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049563 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050506 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23098759 | Mitotic centromere-associated kinase (MCAK/Kif2C) plays a critical role in chromosome movement and segregation with ATP-dependent microtubule depolymerase activity |
| 23098759 | MCAK/Kif2C expression decreased in human primary cells under replicative and premature senescence |
| 23098759 | MCAK/Kif2C down-regulation in young cells induced premature senescence |
| 23098759 | MCAK/Kif2C overexpression in old cells partially reversed cell senescence |
| 23098759 | Senescence phenotypes by MCAK/Kif2C knockdown were observed in p16-knockdown cells, but not in p53-knockdown cells |
| 23098759 | These results suggest that MCAK/Kif2C plays an important role in the regulation of cellular senescence through a p53-dependent pathway and might contribute to tissue/organism aging and protection of cellular transformation |
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