HCSGD entry for CBX1
1. General information
| Official gene symbol | CBX1 |
|---|---|
| Entrez ID | 10951 |
| Gene full name | chromobox homolog 1 |
| Other gene symbols | CBX HP1-BETA HP1Hs-beta HP1Hsbeta M31 MOD1 p25beta |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000775 | Chromosome, centromeric region | IDA | cellular_component |
| GO:0000785 | Chromatin | IDA | cellular_component |
| GO:0001939 | Female pronucleus | IEA | cellular_component |
| GO:0001940 | Male pronucleus | IEA | cellular_component |
| GO:0003682 | Chromatin binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005720 | Nuclear heterochromatin | TAS | cellular_component |
| GO:0005721 | Centromeric heterochromatin | IEA | cellular_component |
| GO:0005819 | Spindle | IDA | cellular_component |
| GO:0010369 | Chromocenter | IEA | cellular_component |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:1990226 | Histone methyltransferase binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9887074617 | 0.0081767448 | 0.9999902473 | 0.1805537752 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3397877289 |
| GSE13712_SHEAR | Down | -0.1457022212 |
| GSE13712_STATIC | Down | -0.1248097439 |
| GSE19018 | Down | -0.0865854607 |
| GSE19899_A1 | Down | -0.7662639481 |
| GSE19899_A2 | Down | -1.3773886814 |
| PubMed_21979375_A1 | Down | -1.1903811533 |
| PubMed_21979375_A2 | Down | -1.2216721943 |
| GSE35957 | Down | -0.5691036109 |
| GSE36640 | Down | -0.4854642731 |
| GSE54402 | Down | -0.2477592434 |
| GSE9593 | Down | -0.4335455070 |
| GSE43922 | Down | -0.4804316193 |
| GSE24585 | Up | 0.3294712905 |
| GSE37065 | Down | -0.2423583802 |
| GSE28863_A1 | Up | 0.0183823351 |
| GSE28863_A2 | Down | -0.2796165773 |
| GSE28863_A3 | Up | 0.0640010037 |
| GSE28863_A4 | Up | 0.1603996293 |
| GSE48662 | Up | 0.1316323891 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003170 | immunoprecipitaion//Microarray//qRT-PCR | Functional MTI (Weak) | 19826008 |
| hsa-miR-590-3p | MIMAT0004801 | MIRT016166 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016475 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021150 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037076 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043713 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25548483 | RESULTS: Senescent hepatocytes induced classical markers of senescence (p21, heterochromatin protein 1beta, and senescence-associated-beta-galactosidase activity); and downregulated the proliferation marker, Ki67 |
| 24763337 | Epigenome rejuvenation: HP1beta mobility as a measure of pluripotent and senescent chromatin ground states |
| 24763337 | We measured the dynamics of an essential epigenetic modifier, HP1beta, in human cells at different stages of differentiation using Fluorescence Recovery After Photobleaching (FRAP) |
| 24763337 | We found that HP1beta mobility is similar in human embryonic stem cells (hES) and iPS cells where it is more mobile compared to fibroblasts; HP1beta is less mobile in senescent fibroblasts than in young (dividing) fibroblasts |
| 24763337 | Introduction of "reprogramming factors", Oct4, Sox2, Klf4, cMyc and Lin28, into senescent fibroblasts and measuring the changes in HP1beta mobility as reprogramming proceeds shows that the mobility of HP1beta in senescent cells increases and by day 9 is the same as that found in young fibroblasts |
| 21677876 | Here we show that androgen deprivation therapy (ADT), a widely used treatment for advanced prostate cancer, induces a senescence-associated secretory phenotype in prostate cancer epithelial cells, indicated by increases in senescence-associated beta-galactosidase activity, heterochromatin protein 1beta foci, and expression of cathepsin B and insulin-like growth factor binding protein 3 |
| 17242207 | In cells entering senescence, HP1gamma, but not the related proteins HP1alpha and HP1beta, becomes phosphorylated on serine 93 |
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