HCSGD entry for BTG3
1. General information
| Official gene symbol | BTG3 |
|---|---|
| Entrez ID | 10950 |
| Gene full name | BTG family, member 3 |
| Other gene symbols | ANA TOB5 TOB55 TOFA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0045930 | Negative regulation of mitotic cell cycle | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8466594278 | 0.0798807796 | 0.9999902473 | 0.5340467361 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0159082569 |
| GSE13712_SHEAR | Up | 0.1219064381 |
| GSE13712_STATIC | Up | 0.1951658441 |
| GSE19018 | Up | 0.1415235097 |
| GSE19899_A1 | Down | -0.3745690671 |
| GSE19899_A2 | Down | -0.3271571196 |
| PubMed_21979375_A1 | Up | 0.2308049557 |
| PubMed_21979375_A2 | Down | -0.4495055255 |
| GSE35957 | Down | -0.2982414628 |
| GSE36640 | Down | -0.7251452452 |
| GSE54402 | Up | 0.0576961115 |
| GSE9593 | Down | -0.3419401430 |
| GSE43922 | Down | -0.3376050826 |
| GSE24585 | Up | 0.3681587477 |
| GSE37065 | Up | 0.6786611746 |
| GSE28863_A1 | Down | -0.3135715039 |
| GSE28863_A2 | Down | -0.1727465078 |
| GSE28863_A3 | Up | 0.0584991004 |
| GSE28863_A4 | Up | 0.1305669405 |
| GSE48662 | Down | -0.5502483503 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002592 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002592 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019633 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020163 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020477 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028053 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039982 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22020331 | Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis |
| 22020331 | The B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and a downstream target of p53 |
| 22020331 | BTG3 also binds and inhibits E2F1 |
| 22020331 | Although it connects functionally two major growth-regulatory pathways, the physiological role of BTG3 remains largely uncharacterized |
| 22020331 | Here, we present evidence that loss of BTG3 in normal cells induced cellular senescence, which was correlated with enhanced ERK-AP1 signaling and elevated expression of the histone H3K27me3 demethylase JMJD3/KDM6B, leading to acute induction of p16(INK4a) |
| 22020331 | Importantly, we also found that BTG3 expression is specifically downregulated in prostate cancer, thus providing a physiological link with human cancers |
| 22020331 | Our data suggest that BTG3 may have a fail-safe role against tumorigenic progression |
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