HCSGD entry for PRDX3
1. General information
| Official gene symbol | PRDX3 |
|---|---|
| Entrez ID | 10935 |
| Gene full name | peroxiredoxin 3 |
| Other gene symbols | AOP-1 AOP1 HBC189 MER5 PRO1748 SP-22 prx-III |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001893 | Maternal placenta development | IEA | biological_process |
| GO:0004601 | Peroxidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0006979 | Response to oxidative stress | IMP | biological_process |
| GO:0007005 | Mitochondrion organization | IMP | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IDA | biological_process |
| GO:0008385 | IkappaB kinase complex | IPI | cellular_component |
| GO:0008785 | Alkyl hydroperoxide reductase activity | NAS | molecular_function |
| GO:0010466 | Negative regulation of peptidase activity | IMP | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | IMP | biological_process |
| GO:0016209 | Antioxidant activity | IEA | molecular_function |
| GO:0019900 | Kinase binding | IPI | molecular_function |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030099 | Myeloid cell differentiation | ISS | biological_process |
| GO:0032496 | Response to lipopolysaccharide | ISS | biological_process |
| GO:0033673 | Negative regulation of kinase activity | IDA | biological_process |
| GO:0034614 | Cellular response to reactive oxygen species | IMP | biological_process |
| GO:0042542 | Response to hydrogen peroxide | IDA | biological_process |
| GO:0042744 | Hydrogen peroxide catabolic process | IGI IMP | biological_process |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0043027 | Cysteine-type endopeptidase inhibitor activity involved in apoptotic process | IMP | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0043281 | Regulation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:0051881 | Regulation of mitochondrial membrane potential | IMP | biological_process |
| GO:0051920 | Peroxiredoxin activity | IEA | molecular_function |
| GO:0052547 | Regulation of peptidase activity | IMP | biological_process |
| GO:0052548 | Regulation of endopeptidase activity | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9014857186 | 0.2650821777 | 0.9999902473 | 0.9867933362 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0916044671 |
| GSE13712_SHEAR | Up | 0.2090935644 |
| GSE13712_STATIC | Up | 0.0793038192 |
| GSE19018 | Down | -0.3362110179 |
| GSE19899_A1 | Up | 0.0907467483 |
| GSE19899_A2 | Down | -0.2248648144 |
| PubMed_21979375_A1 | Up | 0.4143446164 |
| PubMed_21979375_A2 | Down | -0.0632885622 |
| GSE35957 | Down | -0.2572842011 |
| GSE36640 | Up | 0.0008159501 |
| GSE54402 | Up | 0.0430056145 |
| GSE9593 | Down | -0.2135860878 |
| GSE43922 | Down | -0.0089599839 |
| GSE24585 | Down | -0.1639420341 |
| GSE37065 | Down | -0.0688862442 |
| GSE28863_A1 | Up | 0.0016710686 |
| GSE28863_A2 | Up | 0.0978228338 |
| GSE28863_A3 | Down | -0.2169503419 |
| GSE28863_A4 | Up | 0.1339439659 |
| GSE48662 | Down | -0.7836666255 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-383-5p | MIMAT0000738 | MIRT007305 | Luciferase reporter assay | Functional MTI | 23227829 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016299 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-375 | MIMAT0000728 | MIRT019731 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025072 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-320a | MIMAT0000510 | MIRT044454 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046524 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT051339 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
