HCSGD entry for MORF4L1
1. General information
| Official gene symbol | MORF4L1 |
|---|---|
| Entrez ID | 10933 |
| Gene full name | mortality factor 4 like 1 |
| Other gene symbols | Eaf3 HsT17725 MEAF3 MORFRG15 MRG15 S863-6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000724 | Double-strand break repair via homologous recombination | IDA | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0016575 | Histone deacetylation | IDA | biological_process |
| GO:0016580 | Sin3 complex | IDA | cellular_component |
| GO:0035267 | NuA4 histone acetyltransferase complex | IDA | cellular_component |
| GO:0040008 | Regulation of growth | IEA | biological_process |
| GO:0043967 | Histone H4 acetylation | IDA | biological_process |
| GO:0043968 | Histone H2A acetylation | IDA | biological_process |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9663528741 | 0.1162689753 | 0.9999902473 | 0.6536342802 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2669041493 |
| GSE13712_SHEAR | Down | -0.1236117695 |
| GSE13712_STATIC | Down | -0.1695876754 |
| GSE19018 | Up | 0.0776863120 |
| GSE19899_A1 | Down | -0.1239777439 |
| GSE19899_A2 | Down | -0.3180252694 |
| PubMed_21979375_A1 | Down | -0.1939212331 |
| PubMed_21979375_A2 | Down | -0.2861725600 |
| GSE35957 | Up | 0.1914005762 |
| GSE36640 | Down | -0.0922285842 |
| GSE54402 | Down | -0.0945057975 |
| GSE9593 | Up | 0.1091742204 |
| GSE43922 | Down | -0.1548747542 |
| GSE24585 | Up | 0.1156021250 |
| GSE37065 | Up | 0.0928757513 |
| GSE28863_A1 | Down | -0.1608375643 |
| GSE28863_A2 | Down | -0.2261497077 |
| GSE28863_A3 | Down | -0.0146170384 |
| GSE28863_A4 | Up | 0.1574551499 |
| GSE48662 | Down | -0.5870769291 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019410 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT020406 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021448 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT021617 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032039 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039724 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046737 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20600782 | Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster |
| 20600782 | The mammalian MRG15 gene encodes a chromodomain protein predicted to bind to chromatin via methylated histone tails |
| 20600782 | Drosophila contains a single homolog of human MRG15, called DmMRG15 |
| 20600782 | Null mutation of MRG15 is embryonic-lethal in mice and Drosophila, making the study of MRG15 requirements in adults difficult |
| 20536842 | In contrast to MORF4, MRG15 and MRGX are positive regulators of cell division |
| 20536842 | Mrg15 knockout mice are embryonic lethal, and mouse embryonic fibroblasts derived from Mrg15 null embryos proliferate poorly, enter senescence rapidly, and have impaired DNA repair compared to the wild type |
| 20536842 | Mrg15 null embryonic neural stem and progenitor cells also have a decreased capacity for proliferation and differentiation |
| 17460191 | MRG15, the evolutionary ancestor of the family, is highly conserved in yeast, C |
| 17460191 | Our proteomics studies have found that MRG15 is unique among mammalian genes in that it associates with both histone deacetylases and histone acetyl transferase complexes, and thus potentially plays a role in both transcriptional silencing and activation |
| 17135209 | Human MRG15 is a transcription factor that plays a vital role in embryonic development, cell proliferation and cellular senescence |
| 17008723 | The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14 |
| 17008723 | MRG15 is a transcription factor expressed in a variety of human tissues, and its orthologs have been found in many other eukaryotes which constitute the MRG protein family |
| 17008723 | The C-terminal part of MRG15 forms a conserved MRG domain which is involved in interactions with the tumor suppressor protein retinoblastoma and a nucleoprotein PAM14 during transcriptional regulation |
| 17008723 | We report here the characterization of the interaction between the MRG domain of human MRG15 and PAM14 using both yeast two-hybrid and in vitro binding assays based on the crystal structure of the MRG domain |
| 17008723 | Structural and biochemical data together demonstrate that the PAM14 binding site is consisted of residues Ile160, Leu168, Val169, Trp172, Tyr235, Val268, and Arg269 of MRG15, which form a shallow hydrophobic pocket to interact with the N-terminal 50 residues of PAM14 through primarily hydrophobic interactions |
| 17008723 | These results provide the molecular basis for the interaction between the MRG domain and PAM14, and reveal insights into the potential biological function of MRG15 in transcription regulation and chromatin remodeling |
| 16407074 | We present here the crystal structure of a prototypic MRG domain from human MRG15 whose core consists of two orthogonal helix hairpins |
| 15923606 | We have shown that MRGX and MRG15 associate with Rb in nucleoprotein complexes and regulate B-myb promoter activity |
| 15923606 | Characterization of the expression pattern of mouse MrgX demonstrated it was ubiquitously expressed in all tissues of adult mice and also during embryogenesis and overlapped with its homolog Mrg15 |
| 15923606 | MRGX and MRG15 proteins localize predominantly to the chromatin fraction in the nucleus, although a small amount of both proteins localized to the nuclear matrix |
| 15923606 | Whereas disruption of Mrg15 results in embryonic lethality, absence of MrgX did not impair mouse development and MrgX null mice are healthy and fertile |
| 15923606 | Mrg15 expression in MrgX-deficient tissues and MEFs was not upregulated compared with wild-type tissues and MEFs |
| 15923606 | MRG15 is highly conserved with orthologs present from humans to yeast and is essential for survival of mice |
| 15923606 | In contrast, MRGX, which evolved later, is expressed only in vertebrates, suggesting that the lack of phenotype of MrgX-deficient mice is secondary to a compensatory effect by the evolutionarily conserved MRG15 protein but not vice versa |
| 12391155 | Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split |
| 12391155 | This family comprises MORF on chromosome 4 (MORF4) and MORF-related genes on chromosomes X and 15 (MRGX and MRG15, respectively) and is proposed to contribute to cellular senescence |
| 12391155 | While the MORFs may have common functions, MRG15, but not MRGX or MORF4, interacted with Pf1 |
| 12391155 | Therefore, MRG15 may have functions that are distinct from those of MRGX and MORF4 |
| 12391155 | Pf1 has independent binding sites for MRG15 and mSin3A |
| 12391155 | In addition, Pf1 and MRG15 bind different domains on mSin3A |
| 12391155 | Together, these data suggest that the unique functions of MRG15 are elicited through the action of an MRG15/Pf1/mSin3A complex |
| 11500496 | MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14 |
| 11500496 | The MORF4-Related Gene on chromosome 15 (MRG15) is a member of a novel family of genes originally identified in studies to reveal cell senescence-inducing factors |
| 11500496 | MRG15 contains several predicted protein motifs, including a nuclear localization signal, a helix-loop-helix region, a leucine zipper, and a chromodomain |
| 11500496 | These motifs are commonly associated with transcription factors, suggesting that MRG15 may likewise function as a transcriptional regulator |
| 11500496 | To examine the potential function(s) of MRG15, we sought to identify cellular factors associated with this MRG family member |
| 11500496 | We have further demonstrated that these interactions require the helix-loop-helix and leucine zipper domains of MRG15 |
| 11500496 | Significantly we have demonstrated that MRG15 blocks the Rb-induced repression of this promoter, leading to B-myb promoter activation |
| 11500496 | Collectively these results suggest that MRG15 regulates transcription through interactions with a cellular protein complex containing Rb and PAM14 |
| 11280020 | It is a member of a family of seven genes and only MORF4 and the MORF-related genes MRG15 and MRGX are expressed |
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