HCSGD entry for SPIN1
1. General information
| Official gene symbol | SPIN1 |
|---|---|
| Entrez ID | 10927 |
| Gene full name | spindlin 1 |
| Other gene symbols | SPIN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005819 | Spindle | IEA | cellular_component |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0007276 | Gamete generation | IEA | biological_process |
| GO:0035064 | Methylated histone residue binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9498577220 | 0.0667980054 | 0.9999902473 | 0.4875735718 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0102192799 |
| GSE13712_SHEAR | Down | -0.1436227403 |
| GSE13712_STATIC | Down | -0.2513131403 |
| GSE19018 | Down | -0.1476963803 |
| GSE19899_A1 | Down | -0.2720384387 |
| GSE19899_A2 | Down | -0.6595219889 |
| PubMed_21979375_A1 | Down | -1.1831094097 |
| PubMed_21979375_A2 | Down | -0.1883321415 |
| GSE35957 | Down | -0.1527903260 |
| GSE36640 | Down | -0.3698959047 |
| GSE54402 | Down | -0.1043251838 |
| GSE9593 | Down | -0.1539072829 |
| GSE43922 | Down | -0.3708567360 |
| GSE24585 | Up | 0.2068430766 |
| GSE37065 | Up | 0.0644238191 |
| GSE28863_A1 | Up | 0.1739926751 |
| GSE28863_A2 | Up | 0.1649081652 |
| GSE28863_A3 | Down | -0.2254840187 |
| GSE28863_A4 | Up | 0.0554778929 |
| GSE48662 | Up | 0.0290633667 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020543 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022322 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030784 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-598-3p | MIMAT0003266 | MIRT040485 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18201843 | Human or mouse Spindlin1 is expressed in various tissues and cells, but its biological functions are poorly understood |
| 18201843 | In this study, we show that human SPINDLIN1 is localized to interphase nucleus and mitotic chromosomes, and its expression in HeLa cells is not regulated in a cell cycle-dependent manner |
| 18201843 | When SPINDLIN1 is stably overexpressed in HeLa cells, it results in multinucleation of cells, and these multinucleated cells exhibits characteristic features of senescence and apoptosis shown by growth and morphological alterations, beta-galactosidase activity, and Annexin V/7-Aminoactinomycin D staining |
| 18201843 | Mouse Spindlin1 is highly homologous with human Spindlin1, when overexpressed in NIH3T3 cells, it also induces multinucleation, senescence and apoptosis in murine cells |
| 18201843 | Our results demonstrate that SPINDLIN1 is an important gene for mammalian mitotic chromosome functions, and disrupted regulation results in abnormal cell division, a mechanism that may be involved in tumorigenesis |
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