HCSGD entry for SMPDL3A
1. General information
| Official gene symbol | SMPDL3A |
|---|---|
| Entrez ID | 10924 |
| Gene full name | sphingomyelin phosphodiesterase, acid-like 3A |
| Other gene symbols | ASM3A ASML3a yR36GH4.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004767 | Sphingomyelin phosphodiesterase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006685 | Sphingomyelin catabolic process | IEA | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0016798 | Hydrolase activity, acting on glycosyl bonds | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3849830592 | 0.0732049390 | 0.9999902473 | 0.5100124934 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4602537973 |
| GSE13712_SHEAR | Down | -0.3732760259 |
| GSE13712_STATIC | Down | -0.4680727702 |
| GSE19018 | Down | -0.7151568466 |
| GSE19899_A1 | Down | -0.1597135173 |
| GSE19899_A2 | Down | -0.0680275791 |
| PubMed_21979375_A1 | Down | -0.2178905758 |
| PubMed_21979375_A2 | Up | 0.1604100741 |
| GSE35957 | Up | 0.5531510704 |
| GSE36640 | Up | 0.1227065377 |
| GSE54402 | Down | -1.2326384497 |
| GSE9593 | Up | 0.1471038488 |
| GSE43922 | Up | 0.2725145671 |
| GSE24585 | Up | 0.3206578674 |
| GSE37065 | Up | 0.1469819901 |
| GSE28863_A1 | Up | 0.1391501497 |
| GSE28863_A2 | Up | 0.1768135742 |
| GSE28863_A3 | Up | 0.0197433723 |
| GSE28863_A4 | Down | -0.5268877490 |
| GSE48662 | Down | -0.1315276988 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018214 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022831 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029820 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
