HCSGD entry for COPS8
1. General information
| Official gene symbol | COPS8 |
|---|---|
| Entrez ID | 10920 |
| Gene full name | COP9 signalosome subunit 8 |
| Other gene symbols | COP9 CSN8 SGN8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0008180 | COP9 signalosome | IDA | cellular_component |
| GO:0010388 | Cullin deneddylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6441085787 | 0.4876507352 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2316974404 |
| GSE13712_SHEAR | Down | -0.0878479522 |
| GSE13712_STATIC | Down | -0.0980066744 |
| GSE19018 | Down | -0.2718596306 |
| GSE19899_A1 | Up | 0.0284768140 |
| GSE19899_A2 | Down | -0.3180804772 |
| PubMed_21979375_A1 | Up | 0.1708357011 |
| PubMed_21979375_A2 | Down | -0.2561780604 |
| GSE35957 | Up | 0.0201718546 |
| GSE36640 | Up | 0.0913405992 |
| GSE54402 | Up | 0.0899158410 |
| GSE9593 | Up | 0.0031392320 |
| GSE43922 | Up | 0.0119939412 |
| GSE24585 | Up | 0.1147854751 |
| GSE37065 | Up | 0.2081184139 |
| GSE28863_A1 | Down | -0.0748836222 |
| GSE28863_A2 | Up | 0.4692859678 |
| GSE28863_A3 | Down | -0.1802694323 |
| GSE28863_A4 | Down | -0.0679268499 |
| GSE48662 | Down | -0.0903481307 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7i-5p | MIMAT0000415 | MIRT024114 | Western blot | Functional MTI | 21530537 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT032086 | Western blot | Functional MTI | 21530537 |
| hsa-let-7e-3p | MIMAT0004485 | MIRT032094 | Western blot | Functional MTI | 21530537 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT032190 | Western blot | Functional MTI | 21530537 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17968325 | These genes belong to very different biochemical families: csn2 (component of the Cop9 signalosome), aldose reductase (a metabolic enzyme) and brf1 (subunit of the RNA polymerase II complex), S-adenosyl homocysteine hydrolase and Bub1 |
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