HCSGD entry for GADD45G
1. General information
| Official gene symbol | GADD45G |
|---|---|
| Entrez ID | 10912 |
| Gene full name | growth arrest and DNA-damage-inducible, gamma |
| Other gene symbols | CR6 DDIT2 GADD45gamma GRP17 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000185 | Activation of MAPKKK activity | IDA | biological_process |
| GO:0000186 | Activation of MAPKK activity | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0006950 | Response to stress | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0046330 | Positive regulation of JNK cascade | IDA | biological_process |
| GO:0051726 | Regulation of cell cycle | IEA | biological_process |
| GO:1900745 | Positive regulation of p38MAPK cascade | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4199542191 | 0.8387270658 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0332032180 |
| GSE13712_SHEAR | Up | 0.1151886878 |
| GSE13712_STATIC | Down | -0.0237052370 |
| GSE19018 | Up | 0.1829677301 |
| GSE19899_A1 | Up | 0.0454403727 |
| GSE19899_A2 | Down | -0.0578907403 |
| PubMed_21979375_A1 | Up | 0.0764229449 |
| PubMed_21979375_A2 | Down | -0.1891754226 |
| GSE35957 | Up | 0.2449353419 |
| GSE36640 | Up | 0.3520236995 |
| GSE54402 | Up | 0.0147505662 |
| GSE9593 | Down | -0.0312251156 |
| GSE43922 | Down | -0.0082072667 |
| GSE24585 | Up | 0.0424504684 |
| GSE37065 | Up | 0.0275641016 |
| GSE28863_A1 | Down | -0.1433718551 |
| GSE28863_A2 | Down | -0.0267409079 |
| GSE28863_A3 | Up | 0.4251775130 |
| GSE28863_A4 | Up | 0.1060988385 |
| GSE48662 | Down | -0.0844952109 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025170 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26378039 | SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells |
| 26378039 | The essential role of SIP1 in GADD45G activities is further validated in the model of the proteasome inhibitor MG132-induced cell senescence |
| 23897841 | UNLABELLED: Growth arrest and DNA damage 45G (GADD45G), a stress sensor with multiple implications in various biological processes, is down-regulated in a broad spectrum of cancers |
| 23897841 | Ectopic expression of GADD45G robustly elicited senescence in HCC cells and suppressed tumor growth in vivo |
| 23897841 | Impairment of Jak-Stat3 activation caused by GADD45G expression was associated with activation of SH2 domain-containing protein tyrosine phosphatase-2 (Shp2) |
| 23897841 | The decrease or absence of GADD45G expression may be a key event for tumor cells or premalignant liver cells to bypass cellular senescence |
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