HCSGD entry for HCST
1. General information
| Official gene symbol | HCST |
|---|---|
| Entrez ID | 10870 |
| Gene full name | hematopoietic cell signal transducer |
| Other gene symbols | DAP10 KAP10 PIK3AP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | IDA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0043548 | Phosphatidylinositol 3-kinase binding | IDA | molecular_function |
| GO:0050776 | Regulation of immune response | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3810417157 | 0.4040776604 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0543616757 |
| GSE13712_SHEAR | Down | -0.3742537285 |
| GSE13712_STATIC | Up | 0.1745547080 |
| GSE19018 | Up | 0.1036722152 |
| GSE19899_A1 | Down | -0.0305522892 |
| GSE19899_A2 | Up | 0.2130026540 |
| PubMed_21979375_A1 | Up | 0.2264921595 |
| PubMed_21979375_A2 | Up | 0.0659762396 |
| GSE35957 | Up | 0.1860658796 |
| GSE36640 | Up | 0.3102447860 |
| GSE54402 | Down | -0.0134479622 |
| GSE9593 | Up | 0.0423420615 |
| GSE43922 | Up | 0.0925434928 |
| GSE24585 | Up | 0.4820233913 |
| GSE37065 | Down | -0.0378114569 |
| GSE28863_A1 | Down | -0.6927403918 |
| GSE28863_A2 | Down | -0.6696042126 |
| GSE28863_A3 | Down | -0.2013509094 |
| GSE28863_A4 | Down | -0.0109380550 |
| GSE48662 | Up | 0.3850348488 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018108 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16461801 | The signaling pathways of these regulatory receptors are complex and dependent on the individual T cells, some of which express important adapter molecules such as DAP10 and DAP12 |
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