HCSGD entry for RUVBL2
1. General information
| Official gene symbol | RUVBL2 |
|---|---|
| Entrez ID | 10856 |
| Gene full name | RuvB-like 2 (E. coli) |
| Other gene symbols | ECP51 INO80J REPTIN RVB2 TIH2 TIP48 TIP49B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003678 | DNA helicase activity | IDA | molecular_function |
| GO:0003684 | Damaged DNA binding | IEA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA TAS | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0016887 | ATPase activity | IDA | molecular_function |
| GO:0030529 | Ribonucleoprotein complex | IEA | cellular_component |
| GO:0031011 | Ino80 complex | IDA | cellular_component |
| GO:0032508 | DNA duplex unwinding | IDA TAS | biological_process |
| GO:0034644 | Cellular response to UV | IMP | biological_process |
| GO:0035267 | NuA4 histone acetyltransferase complex | IDA | cellular_component |
| GO:0040008 | Regulation of growth | IEA | biological_process |
| GO:0042802 | Identical protein binding | IDA IPI | molecular_function |
| GO:0043141 | ATP-dependent 5'-3' DNA helicase activity | IEA | molecular_function |
| GO:0043967 | Histone H4 acetylation | IDA | biological_process |
| GO:0043968 | Histone H2A acetylation | IDA | biological_process |
| GO:0051082 | Unfolded protein binding | TAS | molecular_function |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3527356445 | 0.4968735762 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0658143929 |
| GSE13712_SHEAR | Up | 0.0227276654 |
| GSE13712_STATIC | Up | 0.1283314264 |
| GSE19018 | Up | 0.1994341655 |
| GSE19899_A1 | Up | 0.0667622411 |
| GSE19899_A2 | Up | 0.4249728918 |
| PubMed_21979375_A1 | Up | 0.9737005503 |
| PubMed_21979375_A2 | Up | 0.0700232848 |
| GSE35957 | Down | -0.6032346947 |
| GSE36640 | Down | -0.8535318413 |
| GSE54402 | Up | 0.1699426278 |
| GSE9593 | Down | -0.3784434099 |
| GSE43922 | Up | 0.1923878753 |
| GSE24585 | Down | -0.3690465681 |
| GSE37065 | Down | -0.2824826600 |
| GSE28863_A1 | Down | -0.0669206351 |
| GSE28863_A2 | Up | 0.0405555110 |
| GSE28863_A3 | Up | 0.0389546168 |
| GSE28863_A4 | Up | 0.1724200726 |
| GSE48662 | Down | -0.0543229074 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036346 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042877 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049723 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22341977 | OBJECTIVES: Reptin is an AAA+ ATPase associated with several complexes involved in chromatin remodeling, transcriptional regulation, DNA damage repair, and telomerase activity |
| 22341977 | RESULTS: Reptin is overexpressed in cancerous tissues compared with tumor adjacent renal tissues |
| 22341977 | CONCLUSIONS: Reptin is overexpressed and aberrantly distributed in RCC |
| 22285491 | RUVBL2 is a novel repressor of ARF transcription |
| 22285491 | Here we report RUVBL2 as a novel transcriptional repressor of ARF |
| 22285491 | Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels |
| 22285491 | In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner |
| 22285491 | Mechanistically, RUVBL2 binds to the distal region of ARF promoter, thus leading to the repression of ARF transcription |
| 22285491 | These results suggest an important role of RUVBL2 in the regulation of ARF-p53 pathway |
| 21763315 | RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer |
| 21763315 | Using SILAC-proteomic analysis and molecular studies, we identified the AAA+ ATPase, RuvBl2 as a transcriptional regulator of hTERT and established that this regulation is through cooperation with Ets-2 |
| 21763315 | In colon cancer patients, nuclear expression of RuvBl2 associated with nuclear expression of hTERT, pEts2 and advanced nodal disease (P<0 |
| 21763315 | These data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences |
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