HCSGD entry for HPSE

1. General information

Official gene symbolHPSE
Entrez ID10855
Gene full nameheparanase
Other gene symbolsHPA HPA1 HPR1 HPSE1 HSE1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004566Beta-glucuronidase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005764LysosomeIDAcellular_component
GO:0005765Lysosomal membraneIEAcellular_component
GO:0005975Carbohydrate metabolic processIEA TASbiological_process
GO:0006027Glycosaminoglycan catabolic processTASbiological_process
GO:0006029Proteoglycan metabolic processTASbiological_process
GO:0007160Cell-matrix adhesionIDAbiological_process
GO:0010575Positive regulation vascular endothelial growth factor productionIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016798Hydrolase activity, acting on glycosyl bondsIEAmolecular_function
GO:0030194Positive regulation of blood coagulationIDAbiological_process
GO:0030200Heparan sulfate proteoglycan catabolic processIDAbiological_process
GO:0030203Glycosaminoglycan metabolic processTASbiological_process
GO:0030305Heparanase activityIDA TASmolecular_function
GO:0033690Positive regulation of osteoblast proliferationIDAbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045545Syndecan bindingIDAmolecular_function
GO:0046983Protein dimerization activityIDAmolecular_function
GO:0051797Regulation of hair follicle developmentIDAbiological_process
GO:0051798Positive regulation of hair follicle developmentIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0061042Vascular wound healingIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00688645950.18751995740.21629892600.8396925485

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0402102775
GSE13712_SHEARUp0.5372521864
GSE13712_STATICDown-0.2812699447
GSE19018Up0.0080738022
GSE19899_A1Up0.4561402142
GSE19899_A2Up3.3284826180
PubMed_21979375_A1Up1.8333308492
PubMed_21979375_A2Up1.6456494307
GSE35957Down-0.4140437701
GSE36640Down-0.1088875570
GSE54402Up3.7984130933
GSE9593Down-0.6068334436
GSE43922Up0.6724356145
GSE24585Up0.3092799785
GSE37065Up0.0598788188
GSE28863_A1Down-0.2065958111
GSE28863_A2Down-1.0560258697
GSE28863_A3Down-0.5580575281
GSE28863_A4Down-0.0661304541
GSE48662Down-0.2430740999

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1258MIMAT0005909MIRT005537Immunohistochemistry//In situ hybridization//Luciferase reporter assay//qRT-PCRFunctional MTI21266359
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26424387When individuals are exposed to stress, the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic- adrenal-medullary (SAM) system can be activated leading to secretion of corticosteroids and catecholamines, respectively
26424387But paradoxically, chronic stimulation of the HPA axis is associated with higher risk of developing cancer
26168818Statistically significant increase of senescence associated beta-galactosidase and p16 expression, and reduced expression of heparanase were observed in tumors from NAX014-treated mice than in tumors from control animals
25622010We studied whether leukocyte telomere length (LTL) is associated with hypothalamic-pituitary-adrenal (HPA) axis responses to psychosocial stress in elderly adults
25622010RESULTS: Mixed model regression analyses showed no linear or non-linear associations between LTL and HPA axis activity during TSST (p-values for LTL main effects >298; p-values for LTLxtime interactions >096)
25622010CONCLUSIONS: Our findings suggest that LTL is not consistently associated with HPA axis activity during a standardized psychosocial stress test in elderly adults
23127296Specifically we propose that exaggerated neurobiological sensitivity to threat in anxious individuals may lead to sustained threat perception, which is accompanied by prolonged activation of threat-related neural circuitry and threat-responsive biological systems including the hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system (ANS), and inflammatory response
23127296Over time, this pattern of responding can promote chronic inflammation through structural and functional brain changes, altered sensitivity of immune cell receptors, dysregulation of the HPA axis and ANS, and accelerated cellular aging
22138440An examination of basal and stress reactive HPA axis activity and telomere length
Entries Per Page
Displaying Page of