HCSGD entry for GJB6
1. General information
| Official gene symbol | GJB6 |
|---|---|
| Entrez ID | 10804 |
| Gene full name | gap junction protein, beta 6, 30kDa |
| Other gene symbols | CX30 DFNA3 DFNA3B DFNB1B ECTD2 ED2 EDH HED HED2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005922 | Connexon complex | IEA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007154 | Cell communication | IEA | biological_process |
| GO:0007605 | Sensory perception of sound | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0042471 | Ear morphogenesis | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0048839 | Inner ear development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6681096045 | 0.6122270354 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0223833305 |
| GSE13712_SHEAR | Down | -0.0831389835 |
| GSE13712_STATIC | Down | -0.0545131492 |
| GSE19018 | Up | 0.0822033568 |
| GSE19899_A1 | Up | 0.1379448795 |
| GSE19899_A2 | Up | 0.1929097455 |
| PubMed_21979375_A1 | Up | 0.2967934174 |
| PubMed_21979375_A2 | Down | -0.2753868408 |
| GSE35957 | Up | 0.0527409148 |
| GSE36640 | Up | 0.0107844729 |
| GSE54402 | Up | 0.1426769044 |
| GSE9593 | Down | -0.0477547932 |
| GSE43922 | Up | 0.0111820484 |
| GSE24585 | Up | 0.0753043975 |
| GSE37065 | Down | -0.0706412094 |
| GSE28863_A1 | Down | -0.1372767943 |
| GSE28863_A2 | Down | -0.3416081618 |
| GSE28863_A3 | Up | 0.3382852387 |
| GSE28863_A4 | Down | -0.0168751587 |
| GSE48662 | Up | 0.0041781167 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017331 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26548576 | Under physiological conditions, the endothelium generates vasodilator signals [prostacyclin, nitric oxide NO and endothelium-dependent hyperpolarization (EDH)], for the regulation of vascular tone |
| 26548576 | The relative importance of these two signals depends on the diameter of the blood vessels: as the diameter of the arteries decreases, the contribution of EDH to the regulation of vascular tone increases |
| 26548576 | The mechanism involved in EDH varies with species and blood vessel types; nevertheless, activation of endothelial intermediate- and small-conductance calcium-activated potassium channels (IKCa and SKCa , respectively) is characteristic of the EDH pathway |
| 26548576 | IKCa - and SKCa -mediated EDH are reduced with endothelial dysfunction, which develops with ageing and hypertension, and is less pronounced in female than in age-matched male until after menopause |
| 26171229 | Aging is accompanied by endothelial dysfunction due to reduced bioavailability of nitric oxide (NO) and/or reduced endothelium-dependent hyperpolarizations (EDH) |
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