HCSGD entry for IQGAP2
1. General information
| Official gene symbol | IQGAP2 |
|---|---|
| Entrez ID | 10788 |
| Gene full name | IQ motif containing GTPase activating protein 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | TAS | molecular_function |
| GO:0005095 | GTPase inhibitor activity | TAS | molecular_function |
| GO:0005096 | GTPase activator activity | IEA | molecular_function |
| GO:0005099 | Ras GTPase activator activity | IEA | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005547 | Phosphatidylinositol-3,4,5-trisphosphate binding | IDA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005874 | Microtubule | IDA | cellular_component |
| GO:0005902 | Microvillus | IEA | cellular_component |
| GO:0007165 | Signal transduction | IEA TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0015629 | Actin cytoskeleton | TAS | cellular_component |
| GO:0043086 | Negative regulation of catalytic activity | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0043395730 | 0.9676537024 | 0.1760215926 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2286361360 |
| GSE13712_SHEAR | Up | 0.0069960830 |
| GSE13712_STATIC | Down | -0.0795437992 |
| GSE19018 | Down | -0.1790841682 |
| GSE19899_A1 | Up | 0.8728331506 |
| GSE19899_A2 | Up | 2.1504598793 |
| PubMed_21979375_A1 | Up | 0.3110449321 |
| PubMed_21979375_A2 | Up | 2.5619517273 |
| GSE35957 | Down | -0.0164779175 |
| GSE36640 | Up | 0.1209868076 |
| GSE54402 | Up | 1.6170430593 |
| GSE9593 | Up | 0.0522412559 |
| GSE43922 | Up | 1.5729100188 |
| GSE24585 | Up | 0.1653280813 |
| GSE37065 | Down | -0.0041962280 |
| GSE28863_A1 | Down | -0.1771127967 |
| GSE28863_A2 | Down | -0.1232755705 |
| GSE28863_A3 | Up | 0.1341182267 |
| GSE28863_A4 | Up | 0.0199291678 |
| GSE48662 | Up | 0.5252292488 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16452628 | Major proteins in the active fractions included actin, calmodulin and IQGAP2 |
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