HCSGD entry for NEK6

1. General information

Official gene symbolNEK6
Entrez ID10783
Gene full nameNIMA-related kinase 6
Other gene symbolsSID6-1512
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleTASbiological_process
GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0000910CytokinesisTASbiological_process
GO:0000922Spindle poleIEAcellular_component
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0004871Signal transducer activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005815Microtubule organizing centerIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007059Chromosome segregationIDAbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007077Mitotic nuclear envelope disassemblyTASbiological_process
GO:0007165Signal transductionIMPbiological_process
GO:0007346Regulation of mitotic cell cycleTASbiological_process
GO:0016607Nuclear speckIEAcellular_component
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0019894Kinesin bindingIPImolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030071Regulation of mitotic metaphase/anaphase transitionIDAbiological_process
GO:0031572G2 DNA damage checkpointIMPbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0051225Spindle assemblyTASbiological_process
GO:2000772Regulation of cellular senescenceTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53951764750.05097586340.99999024730.4245291680

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1055787913
GSE13712_SHEARUp0.3642017448
GSE13712_STATICUp0.2864028698
GSE19018Up0.0772907900
GSE19899_A1Down-0.1506682792
GSE19899_A2Down-0.0610231442
PubMed_21979375_A1Down-0.7399412053
PubMed_21979375_A2Down-0.0323022145
GSE35957Down-0.1274685864
GSE36640Down-0.1288208053
GSE54402Down-0.1306796387
GSE9593Up0.3847958533
GSE43922Down-0.7293500563
GSE24585Down-1.5095436108
GSE37065Down-0.4955683159
GSE28863_A1Up0.5064959009
GSE28863_A2Up0.7931189375
GSE28863_A3Down-0.0946587136
GSE28863_A4Down-0.0978826827
GSE48662Up0.1292932372

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002611Microarray//Microarray;OtherFunctional MTI (Weak)15685193
hsa-miR-24-3pMIMAT0000080MIRT030523MicroarrayFunctional MTI (Weak)19748357
hsa-miR-1307-3pMIMAT0005951MIRT035813CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049722CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21539811Nek6 suppresses the premature senescence of human cancer cells induced by camptothecin and doxorubicin treatment
21539811The mitotic kinase Nek6 has recently been shown to be overexpressed in various cancers and has been implicated in tumorigenesis
21539811Previously, we reported that the down-regulation of Nek6 expression was required for p53-induced senescence
21539811DOX-induced G2/M cell cycle arrest and the reduction in cyclin B and cdc2 levels after DOX treatment were significantly reduced by Nek6 overexpression
21539811In addition, an increase in the intracellular levels of ROS in response to DOX was also inhibited in cells overexpressing Nek6
21539811These results suggest that the increased expression of Nek6 renders cancer cells resistant to premature senescence, and targeting Nek6 could be an efficient strategy for cancer treatment
21099361Nek6 overexpression antagonizes p53-induced senescence in human cancer cells
21099361Nek6 is an NIMA-related kinase that plays a critical role in mitotic cell cycle progression
21099361Recent studies have shown that Nek6 is upregulated in various human cancers, but the function of Nek6 in tumorigenesis is largely unknown
21099361Our data revealed that Nek6 expression is decreased both in both the replicative senescence of human normal fibroblasts and premature senescence induced by p53 expression in EJ human bladder cancer cells and H1299 human lung cancer cells
21099361Interestingly, the enforced expression of Nek6 in EJ and H1299 cells completely suppresses p53-induced senescence, whereas the expression of kinase-dead Nek6 did not affect p53-induced senescence
21099361Mechanistic studies revealed that cell cycle arrest in the G1 and G2/M phases, as well as the reduction of cyclin B and cdc2 protein level upon p53 expression were significantly reduced by Nek6 overexpression
21099361In addition, p53-induced increases in intracellular levels of ROS were also inhibited in cells overexpressing Nek6
21099361These results suggest that the downregulation of Nek6 expression is required for the onset of p53-induced cellular senescence and imply a possible role of Nek6 in tumorigenesis
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