HCSGD entry for PLK2
1. General information
| Official gene symbol | PLK2 |
|---|---|
| Entrez ID | 10769 |
| Gene full name | polo-like kinase 2 |
| Other gene symbols | SNK hPlk2 hSNK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IMP | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004871 | Signal transducer activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005622 | Intracellular | ISS | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005814 | Centriole | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007052 | Mitotic spindle organization | IDA | biological_process |
| GO:0007093 | Mitotic cell cycle checkpoint | ISS | biological_process |
| GO:0007265 | Ras protein signal transduction | ISS | biological_process |
| GO:0007613 | Memory | ISS | biological_process |
| GO:0030425 | Dendrite | ISS | cellular_component |
| GO:0032436 | Positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0032486 | Rap protein signal transduction | ISS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | ISS | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
| GO:0046599 | Regulation of centriole replication | IDA IMP | biological_process |
| GO:0048167 | Regulation of synaptic plasticity | ISS | biological_process |
| GO:0060291 | Long-term synaptic potentiation | ISS | biological_process |
| GO:0060292 | Long term synaptic depression | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0106751833 | 0.0990830744 | 0.2623543417 | 0.6027191125 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2210149287 |
| GSE13712_SHEAR | Up | 0.2294282875 |
| GSE13712_STATIC | Up | 0.4422961355 |
| GSE19018 | Up | 0.9070063854 |
| GSE19899_A1 | Up | 1.1633423910 |
| GSE19899_A2 | Up | 0.1265487347 |
| PubMed_21979375_A1 | Up | 1.2761215224 |
| PubMed_21979375_A2 | Up | 1.3128838065 |
| GSE35957 | Down | -0.2600131906 |
| GSE36640 | Down | -0.7428502024 |
| GSE54402 | Down | -0.7164102863 |
| GSE9593 | Down | -0.0114648844 |
| GSE43922 | Up | 0.4214836931 |
| GSE24585 | Up | 0.6687772325 |
| GSE37065 | Up | 0.2845914784 |
| GSE28863_A1 | Up | 0.3724279185 |
| GSE28863_A2 | Down | -0.6595743284 |
| GSE28863_A3 | Down | -1.2444101077 |
| GSE28863_A4 | Down | -0.2310851031 |
| GSE48662 | Down | -0.6990120190 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-126-3p | MIMAT0000445 | MIRT000344 | Luciferase reporter assay//qRT-PCR | Functional MTI | 18832181 |
| hsa-miR-1 | MIMAT0000416 | MIRT023782 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027672 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
