HCSGD entry for NES
1. General information
| Official gene symbol | NES |
|---|---|
| Entrez ID | 10763 |
| Gene full name | nestin |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | IDA | biological_process |
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005882 | Intermediate filament | NAS | cellular_component |
| GO:0007417 | Central nervous system development | NAS | biological_process |
| GO:0007420 | Brain development | ISS | biological_process |
| GO:0019215 | Intermediate filament binding | ISS | molecular_function |
| GO:0030844 | Positive regulation of intermediate filament depolymerization | ISS | biological_process |
| GO:0031076 | Embryonic camera-type eye development | ISS | biological_process |
| GO:0032091 | Negative regulation of protein binding | IDA | biological_process |
| GO:0043086 | Negative regulation of catalytic activity | IDA | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0045111 | Intermediate filament cytoskeleton | IDA | cellular_component |
| GO:0048858 | Cell projection morphogenesis | IEA | biological_process |
| GO:0072089 | Stem cell proliferation | IMP | biological_process |
| GO:2000179 | Positive regulation of neural precursor cell proliferation | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1188247559 | 0.6453159378 | 0.7070870684 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1100380242 |
| GSE13712_SHEAR | Up | 0.2050471411 |
| GSE13712_STATIC | Up | 0.0315336140 |
| GSE19018 | Down | -0.1221999353 |
| GSE19899_A1 | Up | 0.1016489733 |
| GSE19899_A2 | Down | -0.1825566470 |
| PubMed_21979375_A1 | Down | -0.6139219328 |
| PubMed_21979375_A2 | Up | 0.5897307187 |
| GSE35957 | Down | -0.8468049998 |
| GSE36640 | Up | 0.4495520402 |
| GSE54402 | Up | 0.5869631037 |
| GSE9593 | Down | -0.4148980803 |
| GSE43922 | Up | 0.0516719796 |
| GSE24585 | Up | 0.4265106580 |
| GSE37065 | Down | -0.1160703006 |
| GSE28863_A1 | Down | -0.1073274491 |
| GSE28863_A2 | Up | 0.2398061889 |
| GSE28863_A3 | Down | -0.1950742892 |
| GSE28863_A4 | Up | 0.0970136284 |
| GSE48662 | Up | 0.6446035437 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020595 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT035540 | Luciferase reporter assay | Functional MTI | 23016664 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26149270 | This feature incudes (a) Nestin, involved in stem cell recruitment and glial cell activation; (b) A Kinase anchor protein, released as consequence of mitochondrial damage and Rho activation establishing cell shape and motility; (c) Actin related protein 2/3 complex, involved in actin polymerization and cell shape maintenance |
| 26149270 | Released microRNAs include miR-21 (apoptosis), miR-450 (cell aging, maintenance of contractile tone), miR-107 (Nestin expression, apoptosis), miR-149 (endothelia and extracellular matrix homeostasis) |
| 25879198 | Moreover, undifferentiated STRO-1(+)/c-Kit(+)/CD34(-) hDPSCs did not show any expression of CD271 and nestin, typical neural markers, while STRO-1(+)/c-Kit(+)/CD34(+) hDPSCs expressed both |
| 23634235 | Significant gene list was further analysed by Gene Set Enrichment Analysis (GSEA), and the Normalized Enrichment Score (NES) showed that biological processes such as inflammation, protein transport, apoptosis, and cell redox homeostasis were modulated in senescent fibroblasts treated with gamma -tocotrienol |
| 21811608 | We also found that Tpr depletion impairs the NES [nuclear export sequence]-dependent nuclear export of proteins and causes partial co-depletion of Nup153 |
| 21569253 | It was observed that the expression of the intermediate filament nestin was absent from cultures older than 21 days in vitro (DIV), and the expression of neuronal or astrocytic markers appeared to replace nestin |
| 21029119 | Immunohistochemical observation revealed ABCG2-positive cells localized in the cell-rich zone and nestin in the odontoblastic layer in both groups |
| 20089117 | In this study we report that mutations that disrupt the nuclear export signal (NES) of hTERT render it nuclear but unable to immortalize cells despite retention of catalytic activity in vitro |
| 20089117 | Our data indicate that mutations involving the NES of hTERT are associated with defects in telomere maintenance, mitochondrial function and cellular growth, and suggest targeting this region of hTERT as a potential new strategy for cancer treatment |
| 18358537 | An OBGF400 neuronal phenotype was indicated by the recognition of a transfected neuronal progenitor-cell-specific tubulin-alpha1 gene promoter, intracellular presence of early neuronal markers (TuJ1, neuregulin-1, doublecortin and SOX2) and enhanced expression of neuronal- and progenitor lineage-active genes (MAP2, nestin, ENO and Syn1) compared to that of porcine epithelial cells |
| 17967869 | A mutation of the nuclear export signal (NES) motif identified in the MLF1 sequence enhanced the antiproliferative activity of MLF1 |
| 17967869 | Interestingly, disruption of the MLF1-derived NES sequence completely abolished the growth-promoting activity of NPM-MLF1 in murine fibroblasts and hematopoietic cells |
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