HCSGD entry for CTSC
1. General information
| Official gene symbol | CTSC |
|---|---|
| Entrez ID | 1075 |
| Gene full name | cathepsin C |
| Other gene symbols | CPPI DPP-I DPP1 DPPI HMS JP JPD PALS PDON1 PLS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001913 | T cell mediated cytotoxicity | IEA | biological_process |
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005764 | Lysosome | TAS | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0006508 | Proteolysis | IDA IEA | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | IDA IEA | molecular_function |
| GO:0010033 | Response to organic substance | IEA | biological_process |
| GO:0016505 | Peptidase activator activity involved in apoptotic process | IEA | molecular_function |
| GO:0031404 | Chloride ion binding | IEA | molecular_function |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0043621 | Protein self-association | IEA | molecular_function |
| GO:2001235 | Positive regulation of apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0618936477 | 0.0254816838 | 0.5391219183 | 0.3065372029 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.2738373787 |
| GSE13712_SHEAR | Up | 0.2216522159 |
| GSE13712_STATIC | Up | 0.1929620874 |
| GSE19018 | Up | 0.2486366166 |
| GSE19899_A1 | Down | -1.1504503518 |
| GSE19899_A2 | Down | -0.9171215670 |
| PubMed_21979375_A1 | Down | -0.3082500579 |
| PubMed_21979375_A2 | Down | -0.4457991143 |
| GSE35957 | Down | -0.8412928731 |
| GSE36640 | Up | 1.1329359713 |
| GSE54402 | Down | -0.6071777388 |
| GSE9593 | Down | -1.4495287344 |
| GSE43922 | Up | 0.0016619860 |
| GSE24585 | Down | -0.3509567314 |
| GSE37065 | Up | 0.1096324671 |
| GSE28863_A1 | Up | 0.6862144192 |
| GSE28863_A2 | Up | 1.6870064900 |
| GSE28863_A3 | Up | 0.2411735309 |
| GSE28863_A4 | Down | -0.1959130346 |
| GSE48662 | Down | -0.6140098662 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001372 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-375 | MIMAT0000728 | MIRT019957 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027765 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047909 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | NA | hsa-miR-204 | 20369013 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
