HCSGD entry for MAP3K2
1. General information
Official gene symbol | MAP3K2 |
---|---|
Entrez ID | 10746 |
Gene full name | mitogen-activated protein kinase kinase kinase 2 |
Other gene symbols | MEKK2 MEKK2B |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0000187 | Activation of MAPK activity | TAS | biological_process |
GO:0004672 | Protein kinase activity | IDA | molecular_function |
GO:0004674 | Protein serine/threonine kinase activity | TAS | molecular_function |
GO:0004709 | MAP kinase kinase kinase activity | IEA | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005524 | ATP binding | IEA | molecular_function |
GO:0005634 | Nucleus | IEA | cellular_component |
GO:0005829 | Cytosol | IEA | cellular_component |
GO:0006468 | Protein phosphorylation | TAS | biological_process |
GO:0007257 | Activation of JUN kinase activity | TAS | biological_process |
GO:0019901 | Protein kinase binding | IPI | molecular_function |
GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
GO:0046872 | Metal ion binding | IEA | molecular_function |
GO:0071260 | Cellular response to mechanical stimulus | IEP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.4194261426 | 0.3234881008 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.1641160717 |
GSE13712_SHEAR | Up | 0.1736918894 |
GSE13712_STATIC | Up | 0.0218643426 |
GSE19018 | Down | -0.0218379309 |
GSE19899_A1 | Up | 0.1689308152 |
GSE19899_A2 | Down | -0.1685698975 |
PubMed_21979375_A1 | Down | -0.2495821509 |
PubMed_21979375_A2 | Down | -0.0797772546 |
GSE35957 | Up | 0.0524522286 |
GSE36640 | Up | 0.1057263250 |
GSE54402 | Up | 0.2147027055 |
GSE9593 | Down | -0.1328018646 |
GSE43922 | Up | 0.4834173060 |
GSE24585 | Down | -0.0209898944 |
GSE37065 | Up | 0.2698765557 |
GSE28863_A1 | Up | 0.2808301154 |
GSE28863_A2 | Up | 0.3232884245 |
GSE28863_A3 | Down | -0.8491535674 |
GSE28863_A4 | Down | -0.4685558183 |
GSE48662 | Down | -0.0789860004 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
---|---|---|
Bosutinib | DB06616 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-520b | MIMAT0002843 | MIRT006282 | Luciferase reporter assay | Functional MTI | 22319632 |
hsa-miR-26a-5p | MIMAT0000082 | MIRT003212 | GFP reporter assay//Luciferase reporter assay//Western blot | Functional MTI | 20080666 |
hsa-miR-21-5p | MIMAT0000076 | MIRT030767 | Microarray | Functional MTI (Weak) | 18591254 |
hsa-miR-615-3p | MIMAT0003283 | MIRT040386 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-92b-3p | MIMAT0003218 | MIRT040708 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-125b-5p | MIMAT0000423 | MIRT045942 | CLASH | Functional MTI (Weak) | 23622248 |
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