HCSGD entry for MAP3K2


1. General information

Official gene symbolMAP3K2
Entrez ID10746
Gene full namemitogen-activated protein kinase kinase kinase 2
Other gene symbolsMEKK2 MEKK2B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityTASmolecular_function
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007257Activation of JUN kinase activityTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41942614260.32348810080.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1641160717
GSE13712_SHEARUp0.1736918894
GSE13712_STATICUp0.0218643426
GSE19018Down-0.0218379309
GSE19899_A1Up0.1689308152
GSE19899_A2Down-0.1685698975
PubMed_21979375_A1Down-0.2495821509
PubMed_21979375_A2Down-0.0797772546
GSE35957Up0.0524522286
GSE36640Up0.1057263250
GSE54402Up0.2147027055
GSE9593Down-0.1328018646
GSE43922Up0.4834173060
GSE24585Down-0.0209898944
GSE37065Up0.2698765557
GSE28863_A1Up0.2808301154
GSE28863_A2Up0.3232884245
GSE28863_A3Down-0.8491535674
GSE28863_A4Down-0.4685558183
GSE48662Down-0.0789860004

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

BosutinibDB06616 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-520bMIMAT0002843MIRT006282Luciferase reporter assayFunctional MTI22319632
hsa-miR-26a-5pMIMAT0000082MIRT003212GFP reporter assay//Luciferase reporter assay//Western blotFunctional MTI20080666
hsa-miR-21-5pMIMAT0000076MIRT030767MicroarrayFunctional MTI (Weak)18591254
hsa-miR-615-3pMIMAT0003283MIRT040386CLASHFunctional MTI (Weak)23622248
hsa-miR-92b-3pMIMAT0003218MIRT040708CLASHFunctional MTI (Weak)23622248
hsa-miR-125b-5pMIMAT0000423MIRT045942CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.