HCSGD entry for SIX2
1. General information
| Official gene symbol | SIX2 |
|---|---|
| Entrez ID | 10736 |
| Gene full name | SIX homeobox 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001822 | Kidney development | IMP | biological_process |
| GO:0002062 | Chondrocyte differentiation | IEA | biological_process |
| GO:0003337 | Mesenchymal to epithelial transition involved in metanephros morphogenesis | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006606 | Protein import into nucleus | IEA | biological_process |
| GO:0007501 | Mesodermal cell fate specification | IEA | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0042474 | Middle ear morphogenesis | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045596 | Negative regulation of cell differentiation | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0048701 | Embryonic cranial skeleton morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6299318947 | 0.4375341134 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0217650037 |
| GSE13712_SHEAR | Up | 0.0121101802 |
| GSE13712_STATIC | Down | -0.1419053584 |
| GSE19018 | Up | 0.1055842029 |
| GSE19899_A1 | Up | 0.0445947653 |
| GSE19899_A2 | Up | 0.0995800280 |
| PubMed_21979375_A1 | Down | -0.2320465068 |
| PubMed_21979375_A2 | Down | -0.0767003662 |
| GSE35957 | Down | -0.7633727222 |
| GSE36640 | Up | 0.0497588788 |
| GSE54402 | Down | -0.0598676541 |
| GSE9593 | Up | 0.0676296370 |
| GSE43922 | Up | 0.1212835347 |
| GSE24585 | Down | -0.1075878946 |
| GSE37065 | Down | -0.3072748986 |
| GSE28863_A1 | Down | -0.1726978759 |
| GSE28863_A2 | Up | 0.0681164145 |
| GSE28863_A3 | Up | 0.3264214048 |
| GSE28863_A4 | Up | 0.0927017313 |
| GSE48662 | Up | 0.3406841205 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23841748 | Here, using quantitative RT-PCR and flow cytometry [fluorescence-activated cell sorting (FACS)] analysis, we show in VPA-treated primary cultures of human adult and fetal kidney significant reinduction of the renal stem/progenitor markers SIX2, OSR1, SALL1, NCAM, and PSA-NCAM |
| 23841748 | Robust SIX2 mRNA re-expression was confirmed at the protein level by western blot and was associated with epigenetic changes of the histones at multiple sites of the SIX2 promoter leading to gene activation, significantly increased acetylation of histones H4, and methylation of lysine 4 on H3 |
| 23841748 | Furthermore, we could demonstrate synergistic effects of VPA and Wnt antagonists on SIX2 and also OSR1 reinduction |
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