HCSGD entry for PLK4
1. General information
| Official gene symbol | PLK4 |
|---|---|
| Entrez ID | 10733 |
| Gene full name | polo-like kinase 4 |
| Other gene symbols | SAK STK18 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA ISS | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005730 | Nucleolus | ISS | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005814 | Centriole | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007099 | Centriole replication | IMP | biological_process |
| GO:0032154 | Cleavage furrow | IEA | cellular_component |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0046601 | Positive regulation of centriole replication | IMP | biological_process |
| GO:0060707 | Trophoblast giant cell differentiation | ISS | biological_process |
| GO:0098535 | De novo centriole assembly | ISS | biological_process |
| GO:0098536 | Deuterosome | ISS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9894295050 | 0.0000268303 | 0.9999902473 | 0.0091714286 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4540926727 |
| GSE13712_SHEAR | Down | -0.1979750776 |
| GSE13712_STATIC | Down | -0.5689646553 |
| GSE19018 | Down | -0.0759687375 |
| GSE19899_A1 | Down | -0.5372592073 |
| GSE19899_A2 | Down | -3.9364664883 |
| PubMed_21979375_A1 | Down | -3.2719246558 |
| PubMed_21979375_A2 | Down | -4.1665497976 |
| GSE35957 | Down | -1.9411465709 |
| GSE36640 | Down | -5.2019101502 |
| GSE54402 | Down | -0.8443268194 |
| GSE9593 | Down | -1.1906035417 |
| GSE43922 | Down | -2.6956094858 |
| GSE24585 | Up | 0.0121942317 |
| GSE37065 | Down | -0.6828080258 |
| GSE28863_A1 | Down | -0.4232555797 |
| GSE28863_A2 | Up | 0.9489772668 |
| GSE28863_A3 | Down | -0.6114819332 |
| GSE28863_A4 | Down | -0.0419278647 |
| GSE48662 | Down | -1.1739423660 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024738 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026169 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
