HCSGD entry for TCFL5
1. General information
| Official gene symbol | TCFL5 |
|---|---|
| Entrez ID | 10732 |
| Gene full name | transcription factor-like 5 (basic helix-loop-helix) |
| Other gene symbols | CHA E2BP-1 Figlb bHLHe82 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001673 | Male germ cell nucleus | IEA | cellular_component |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0007283 | Spermatogenesis | IEP | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0042127 | Regulation of cell proliferation | IEP | biological_process |
| GO:0045595 | Regulation of cell differentiation | IEP | biological_process |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1025539645 | 0.8317865621 | 0.6666640899 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0586479981 |
| GSE13712_SHEAR | Down | -0.2184174759 |
| GSE13712_STATIC | Down | -0.1001434001 |
| GSE19018 | Up | 0.4245885149 |
| GSE19899_A1 | Up | 0.0923272407 |
| GSE19899_A2 | Up | 0.8201178094 |
| PubMed_21979375_A1 | Up | 0.4211063066 |
| PubMed_21979375_A2 | Up | 0.4371928780 |
| GSE35957 | Up | 0.3501919807 |
| GSE36640 | Up | 0.2876115370 |
| GSE54402 | Up | 0.4820368868 |
| GSE9593 | Up | 0.3419627669 |
| GSE43922 | Down | -0.0381028953 |
| GSE24585 | Down | -0.0336780307 |
| GSE37065 | Down | -0.1532940073 |
| GSE28863_A1 | Down | -0.0107498807 |
| GSE28863_A2 | Up | 0.0402641322 |
| GSE28863_A3 | Down | -0.5838629626 |
| GSE28863_A4 | Up | 0.1070786255 |
| GSE48662 | Up | 0.0611431352 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024939 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026827 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041545 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043570 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051271 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17586465 | To extend the lifespan of mADSCs, two culture conditions containing hyaluronan (HA) was compared in our study, one as a culture medium supplement (SHA), and the other where HA was pre-coated on culture surface (CHA) |
| 17586465 | Upon CHA treatment, mADSCs tended to form cell aggregates with gradual growth profiles, while their differentiation activities remained similar to SHA groups |
| 17586465 | After transferring mADSCs from CHA to control surface, they were shown to have an extended lifespan and an increase of osteogenic potential |
| 17227291 | The growth of stimulated lymphocytes in the presence glucose antimetabolite 2-deoxy-D-glucose led to markedly lowered translational activity, decreased ROS generation and correspondingly attenuated CHA and CAA |
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