HCSGD entry for CFL2
1. General information
| Official gene symbol | CFL2 |
|---|---|
| Entrez ID | 1073 |
| Gene full name | cofilin 2 (muscle) |
| Other gene symbols | NEM7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0015629 | Actin cytoskeleton | IEA | cellular_component |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0030042 | Actin filament depolymerization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9575810759 | 0.0127490597 | 0.9999902473 | 0.2229687708 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2725614898 |
| GSE13712_SHEAR | Up | 0.1606111894 |
| GSE13712_STATIC | Up | 0.1225967686 |
| GSE19018 | Up | 0.6145120728 |
| GSE19899_A1 | Down | -1.3974459122 |
| GSE19899_A2 | Down | -0.3593874232 |
| PubMed_21979375_A1 | Down | -0.6110775044 |
| PubMed_21979375_A2 | Down | -0.8254924344 |
| GSE35957 | Up | 0.1460581646 |
| GSE36640 | Down | -0.0071737625 |
| GSE54402 | Down | -0.3696677676 |
| GSE9593 | Up | 0.1428095334 |
| GSE43922 | Down | -0.7663693187 |
| GSE24585 | Up | 0.0474273004 |
| GSE37065 | Down | -0.4560479171 |
| GSE28863_A1 | Down | -0.2971851821 |
| GSE28863_A2 | Down | -0.4161375260 |
| GSE28863_A3 | Down | -0.3004837155 |
| GSE28863_A4 | Up | 0.0109225572 |
| GSE48662 | Down | -0.4109504375 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT002475 | proteomics analysis | Functional MTI (Weak) | 18362358 |
| hsa-miR-373-3p | MIMAT0000726 | MIRT002526 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-375 | MIMAT0000728 | MIRT019819 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020703 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024888 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026396 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047949 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052465 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | NA | hsa-miR-21 | {Western blot} | {overexpression by miRNA precursor transfection} | 17991735 | |
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | proteomics analysis | overexpression | 18362358 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26640786 | RESULTS: Comparison of protein pattern of senescent and young HPMC revealed 29 differentially abundant protein spots, 11 of which were identified to be actin (cytoplasmic 1 and 2), cytokeratin-7, cofilin-2, transgelin-2, Hsp60, Hsc70, proteasome beta-subunits (type-2 and type-3), nucleoside diphosphate kinase A, and cytosolic 5'(3')-deoxyribonucleotidase |
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