HCSGD entry for NFAT5
1. General information
| Official gene symbol | NFAT5 |
|---|---|
| Entrez ID | 10725 |
| Gene full name | nuclear factor of activated T-cells 5, tonicity-responsive |
| Other gene symbols | NF-AT5 NFATL1 NFATZ OREBP TONEBP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001816 | Cytokine production | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007588 | Excretion | TAS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0070884 | Regulation of calcineurin-NFAT signaling cascade | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0395511037 | 0.6146215075 | 0.4474850451 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0721757317 |
| GSE13712_SHEAR | Down | -0.3270669265 |
| GSE13712_STATIC | Down | -0.2614480424 |
| GSE19018 | Up | 0.0919547664 |
| GSE19899_A1 | Down | -0.0287698383 |
| GSE19899_A2 | Down | -0.2504927501 |
| PubMed_21979375_A1 | Down | -0.6785421992 |
| PubMed_21979375_A2 | Up | 1.0148644011 |
| GSE35957 | Up | 0.6063694824 |
| GSE36640 | Up | 1.7201499454 |
| GSE54402 | Down | -0.0468837624 |
| GSE9593 | Up | 0.4078350142 |
| GSE43922 | Down | -0.5431377092 |
| GSE24585 | Up | 0.3876321647 |
| GSE37065 | Up | 0.2335596377 |
| GSE28863_A1 | Up | 0.4936012381 |
| GSE28863_A2 | Up | 0.5653602212 |
| GSE28863_A3 | Down | -0.2788994446 |
| GSE28863_A4 | Down | -0.0407613506 |
| GSE48662 | Up | 0.2879065970 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-31-5p | MIMAT0000089 | MIRT004971 | Luciferase reporter assay//qRT-PCR | Non-Functional MTI | 19524507 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT005398 | qRT-PCR | Functional MTI (Weak) | 19296935 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT005398 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018093 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030927 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037220 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039549 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050877 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
