HCSGD entry for POLQ
1. General information
| Official gene symbol | POLQ |
|---|---|
| Entrez ID | 10721 |
| Gene full name | polymerase (DNA directed), theta |
| Other gene symbols | POLH PRO0327 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003684 | Damaged DNA binding | TAS | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006261 | DNA-dependent DNA replication | IDA TAS | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0043142 | Single-stranded DNA-dependent ATPase activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9779133316 | 0.0034386421 | 0.9999902473 | 0.1190901316 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0725728292 |
| GSE13712_SHEAR | Up | 0.1187429183 |
| GSE13712_STATIC | Down | -0.0878890364 |
| GSE19018 | Up | 0.0456784045 |
| GSE19899_A1 | Down | -0.0163006164 |
| GSE19899_A2 | Down | -2.3024488668 |
| PubMed_21979375_A1 | Down | -1.0620500536 |
| PubMed_21979375_A2 | Down | -1.9401367487 |
| GSE35957 | Down | -0.8089839072 |
| GSE36640 | Down | -2.4563504396 |
| GSE54402 | Down | -0.4130490178 |
| GSE9593 | Down | -0.2870126188 |
| GSE43922 | Down | -0.9243905286 |
| GSE24585 | Down | -0.2426282399 |
| GSE37065 | Down | -0.2118130506 |
| GSE28863_A1 | Up | 0.0211383579 |
| GSE28863_A2 | Up | 0.4547400172 |
| GSE28863_A3 | Up | 0.0326521945 |
| GSE28863_A4 | Down | -0.0290282280 |
| GSE48662 | Down | -1.0882558701 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016401 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026348 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047989 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26240351 | DNA polymerase eta (pol eta), encoded by the xeroderma pigmentosum (XP-V) gene, plays an essential role in preventing cutaneous cancer caused by UV radiation-induced DNA damage |
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