HCSGD entry for ADCY1

1. General information

Official gene symbolADCY1
Entrez ID107
Gene full nameadenylate cyclase 1 (brain)
Other gene symbolsAC1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007409AxonogenesisIEAbiological_process
GO:0007616Long-term memoryIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0008294Calcium- and calmodulin-responsive adenylate cyclase activityNASmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009190Cyclic nucleotide biosynthetic processIEAbiological_process
GO:0010226Response to lithium ionIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016849Phosphorus-oxygen lyase activityIEAmolecular_function
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67612978610.86997623950.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0232028885
GSE13712_SHEARUp0.0066820598
GSE13712_STATICDown-0.0474619401
GSE19018Up0.0101388984
GSE19899_A1Up0.0293593996
GSE19899_A2Up0.0748808876
PubMed_21979375_A1Down-0.3634380523
PubMed_21979375_A2Down-0.0492155679
GSE35957Up0.1514708132
GSE36640Down-0.1039304487
GSE54402Down-0.0208287874
GSE9593Up0.0468629642
GSE43922Up0.0214847332
GSE24585Up0.0349356189
GSE37065Down-0.1243797787
GSE28863_A1Up0.0827346086
GSE28863_A2Up0.4585638182
GSE28863_A3Up0.2347469051
GSE28863_A4Up0.1396936059
GSE48662Up0.0178941549

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-423-3pMIMAT0001340MIRT042602CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043290CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044544CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052078CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.