HCSGD entry for CD226
1. General information
| Official gene symbol | CD226 |
|---|---|
| Entrez ID | 10666 |
| Gene full name | CD226 molecule |
| Other gene symbols | DNAM-1 DNAM1 PTA1 TLiSA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001816 | Cytokine production | IEA | biological_process |
| GO:0002860 | Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | IMP | biological_process |
| GO:0002891 | Positive regulation of immunoglobulin mediated immune response | IDA | biological_process |
| GO:0005178 | Integrin binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008037 | Cell recognition | TAS | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0033005 | Positive regulation of mast cell activation | IDA | biological_process |
| GO:0045121 | Membrane raft | TAS | cellular_component |
| GO:0045954 | Positive regulation of natural killer cell mediated cytotoxicity | IMP | biological_process |
| GO:0050776 | Regulation of immune response | TAS | biological_process |
| GO:0050839 | Cell adhesion molecule binding | IPI | molecular_function |
| GO:0060369 | Positive regulation of Fc receptor mediated stimulatory signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8321610691 | 0.2420311880 | 0.9999902473 | 0.9477526778 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1583795345 |
| GSE13712_SHEAR | Down | -0.3965420813 |
| GSE13712_STATIC | Down | -0.0561959750 |
| GSE19018 | Down | -0.1363448688 |
| GSE19899_A1 | Down | -0.0935512768 |
| GSE19899_A2 | Down | -0.1774636289 |
| PubMed_21979375_A1 | Up | 0.0825061949 |
| PubMed_21979375_A2 | Up | 0.2450328896 |
| GSE35957 | Down | -0.0888409036 |
| GSE36640 | Up | 0.4110008290 |
| GSE54402 | Up | 0.0269529938 |
| GSE9593 | Up | 0.0521959180 |
| GSE43922 | Up | 0.0147879319 |
| GSE24585 | Down | -0.2144068071 |
| GSE37065 | Up | 0.2837665909 |
| GSE28863_A1 | Down | -0.2012262966 |
| GSE28863_A2 | Down | -0.6452257121 |
| GSE28863_A3 | Up | 0.0936644638 |
| GSE28863_A4 | Down | -0.0864260954 |
| GSE48662 | Down | -0.0048518116 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018110 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27853638 | Melphalan treatment was able to enhance the surface expression of the stress-induced NKG2D ligands RAE-1 and MULT-1, and of the DNAM-1 ligand PVR (CD155) on MM cells, leading to better tumor cell recognition and killing by NK cells, as highlighted by NK cell increased degranulation triggered by melphalan-treated tumor cells |
| 24913980 | In this article, we identify the signaling events underlying chemotherapy-induced NKG2D and DNAM-1 ligand expression on multiple myeloma (MM) cells |
| 19098271 | ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype |
| 19098271 | Induction of DNA damage response has been recently shown capable of enhancing NKG2D ligand (NKG2DL) expression, but nothing is known about DNAM-1 ligand (DNAM-1L) regulation |
| 19098271 | In this study, we show that myeloma cells treated with low doses of therapeutic agents commonly used in the management of patients with MM, such as doxorubicin, melphalan, and bortezomib, up-regulate DNAM-1 and NKG2D ligands |
| 19098271 | Accordingly, therapeutic drug treatment of MM cells increases NK-cell degranulation, the NKG2D and DNAM-1 receptors being the major triggering molecules |
| 19098271 | Drug-induced DNAM-1 and NKG2D ligand expression was abolished after treatment with the ATM (ataxia telangiectasia mutated) and ATR (ATM- and RAD3-related) pharmacologic inhibitors caffeine and KU-55933, and was preferentially associated with senescent cells arrested in the G2 phase of the cell cycle |
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