HCSGD entry for CXCR6
1. General information
| Official gene symbol | CXCR6 |
|---|---|
| Entrez ID | 10663 |
| Gene full name | chemokine (C-X-C motif) receptor 6 |
| Other gene symbols | BONZO CD186 STRL33 TYMSTR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006935 | Chemotaxis | IEA | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0015026 | Coreceptor activity | IEA | molecular_function |
| GO:0016494 | C-X-C chemokine receptor activity | IEA | molecular_function |
| GO:0019079 | Viral genome replication | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8406794461 | 0.6525554728 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0507076725 |
| GSE13712_SHEAR | Down | -0.0686744303 |
| GSE13712_STATIC | Down | -0.0416996251 |
| GSE19018 | Up | 0.1456847996 |
| GSE19899_A1 | Up | 0.0726931733 |
| GSE19899_A2 | Up | 0.1582637593 |
| PubMed_21979375_A1 | Up | 0.0249596867 |
| PubMed_21979375_A2 | Down | -0.1414818206 |
| GSE35957 | Down | -0.0219806348 |
| GSE36640 | Down | -0.0253622682 |
| GSE54402 | Down | -0.0498082494 |
| GSE9593 | Up | 0.1097493905 |
| GSE43922 | Up | 0.0510074783 |
| GSE24585 | Down | -0.1937506158 |
| GSE37065 | Up | 0.0012844546 |
| GSE28863_A1 | Down | -0.0679781912 |
| GSE28863_A2 | Down | -0.1544711449 |
| GSE28863_A3 | Down | -0.0655299888 |
| GSE28863_A4 | Up | 0.0015553545 |
| GSE48662 | Up | 0.0294279899 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029190 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26272362 | The chemokine CXCL16 and its receptor, C-X-C chemokine receptor (CXCR6), affect tumor progression through different pathways, including leukocyte recruitment and function, cellular senescence, tumor cell proliferation, survival, invasion, and metastasis |
| 26272362 | As a conclusion, high protein expression of CXCL16 and high protein co-expression of CXCL16/CXCR6 in PC were independent predictors for a worse clinical outcome |
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