HCSGD entry for CELF1
1. General information
| Official gene symbol | CELF1 |
|---|---|
| Entrez ID | 10658 |
| Gene full name | CUGBP, Elav-like family member 1 |
| Other gene symbols | BRUNOL2 CUG-BP CUGBP CUGBP1 EDEN-BP NAB50 NAPOR hNab50 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000900 | Translation repressor activity, nucleic acid binding | NAS | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IDA IEA | molecular_function |
| GO:0003729 | MRNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | NAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006376 | MRNA splice site selection | IEA ISS | biological_process |
| GO:0006397 | MRNA processing | TAS | biological_process |
| GO:0006417 | Regulation of translation | NAS | biological_process |
| GO:0007281 | Germ cell development | NAS | biological_process |
| GO:0007286 | Spermatid development | IEA | biological_process |
| GO:0009790 | Embryo development | NAS | biological_process |
| GO:0016246 | RNA interference | NAS | biological_process |
| GO:0017148 | Negative regulation of translation | NAS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | NAS | cellular_component |
| GO:0031369 | Translation initiation factor binding | IEA | molecular_function |
| GO:0040018 | Positive regulation of multicellular organism growth | IEA | biological_process |
| GO:0042835 | BRE binding | IDA | molecular_function |
| GO:0043484 | Regulation of RNA splicing | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1787905817 | 0.9148665666 | 0.8289903697 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0848057202 |
| GSE13712_SHEAR | Up | 0.2379347892 |
| GSE13712_STATIC | Up | 0.1101592714 |
| GSE19018 | Down | -0.0083081813 |
| GSE19899_A1 | Up | 0.1407645509 |
| GSE19899_A2 | Up | 0.3460294923 |
| PubMed_21979375_A1 | Up | 0.1873784786 |
| PubMed_21979375_A2 | Down | -0.0318675449 |
| GSE35957 | Down | -0.1199050976 |
| GSE36640 | Down | -0.0701216155 |
| GSE54402 | Up | 0.3870240951 |
| GSE9593 | Down | -0.0353104474 |
| GSE43922 | Down | -0.0449820918 |
| GSE24585 | Up | 0.0115506468 |
| GSE37065 | Down | -0.1358812865 |
| GSE28863_A1 | Up | 0.1192591945 |
| GSE28863_A2 | Up | 0.3324563672 |
| GSE28863_A3 | Down | -0.4723919802 |
| GSE28863_A4 | Up | 0.1477590714 |
| GSE48662 | Up | 0.9046390123 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036047 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040833 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 14726956 | Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate |
| 14726956 | Two RNA-binding proteins, CUGBP1 and calreticulin (CRT), interact with the same nucleotide sequences within the 5' region of p21 mRNA, but have opposite effects on the translation of p21 mRNA |
| 14726956 | CUGBP1 increases translation of p21 mRNA, whereas CRT blocks translation of p21 via stabilization of a stem-loop structure within the 5' region of the p21 mRNA |
| 14726956 | CUGBP1 and CRT compete for binding to p21 mRNA and thereby the regulation of p21 translation |
| 14726956 | In senescent fibroblasts, CUGBP1 displaces CRT from the p21 mRNA and releases CRT-dependent repression of p21 translation leading to growth arrest and development of a senescent phenotype |
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