HCSGD entry for TXNIP

1. General information

Official gene symbolTXNIP
Entrez ID10628
Gene full namethioredoxin interacting protein
Other gene symbolsEST01027 HHCPA78 THIF VDUP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0004857Enzyme inhibitor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005758Mitochondrial intermembrane spaceIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006606Protein import into nucleusIEAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0030216Keratinocyte differentiationIDAbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032355Response to estradiolIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048008Platelet-derived growth factor receptor signaling pathwayIEAbiological_process
GO:0051592Response to calcium ionIEAbiological_process
GO:0051782Negative regulation of cell divisionIDAbiological_process
GO:0071228Cellular response to tumor cellIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00055195470.24032203940.06664220180.9438251865

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0111309421
GSE13712_SHEARUp0.2920447511
GSE13712_STATICDown-1.2931398010
GSE19018Up1.1694409487
GSE19899_A1Up1.5265306238
GSE19899_A2Down-0.2144056213
PubMed_21979375_A1Up1.4402314334
PubMed_21979375_A2Up0.6689966321
GSE35957Up0.0281328565
GSE36640Up1.1925929781
GSE54402Down-0.7209958480
GSE9593Down-0.4564239253
GSE43922Up1.3743497467
GSE24585Up1.5270707752
GSE37065Down-0.1691117610
GSE28863_A1Up1.0285803608
GSE28863_A2Up1.5030963026
GSE28863_A3Up0.3874658124
GSE28863_A4Down-0.3317593314
GSE48662Down-0.6181555163

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-373-3pMIMAT0000726MIRT005561Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21271679
hsa-miR-148b-3pMIMAT0000759MIRT019486MicroarrayFunctional MTI (Weak)17612493
hsa-miR-128-3pMIMAT0000424MIRT022063MicroarrayFunctional MTI (Weak)17612493
hsa-miR-183-5pMIMAT0000261MIRT025014SequencingFunctional MTI (Weak)20371350
hsa-miR-34a-5pMIMAT0000255MIRT025554SequencingFunctional MTI (Weak)20371350
hsa-miR-378a-3pMIMAT0000732MIRT043886CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25754218Furthermore, both foam cells and 4-HNE increased the expression of the pro-oxidant thioredoxin-interacting protein (TXNIP)
25754218Molecular manipulation of TXNIP expression confirmed its involvement in foam cell-induced senescence
25754218Pharmacological interventions supported the involvement of the 4-HNE-PPARdelta axis in the induction of TXNIP and VEC senescence
25754218The association of TXNIP with VEC senescence was further supported by immunofluorescent staining of human carotid plaques in which the expression of both TXNIP and p21 was augmented in endothelial cells
25754218Collectively, these findings suggest that foam cell-released 4-HNE activates PPARdelta in VEC, leading to increased TXNIP expression and consequently to senescence
20656682Vitamin D(3) up-regulated protein 1 (VDUP1) plays multifunctional roles in diverse cellular responses, particularly in its relation to proliferation, apoptosis, differentiation, and diseases such as cancer and stress-related diseases
20656682In this study, we demonstrated that VDUP1 was up-regulated during the senescence process
20656682Our results showed that overexpression of VDUP1 in young cells caused typical signs of senescence
20656682We also found that VDUP1 knockdown delayed the onset of Ras-induced cellular senescence
20656682Subsequently, we found that FOXO3A, whose activity increased in senescent cells, transcriptionally up-regulates VDUP1 expression and miR-17-5p, whose expression decreased in senescent cells, directly interacted with the 3'-untranslated region of VDUP1 transcripts, and destabilized VDUP1 mRNA in young cells
20656682These results indicated that VDUP1 expression was regulated by FOXO3A at the transcriptional level and by miR-17-5p at the post-transcriptional levels during the senescence process
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