HCSGD entry for PAICS
1. General information
| Official gene symbol | PAICS |
|---|---|
| Entrez ID | 10606 |
| Gene full name | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
| Other gene symbols | ADE2 ADE2H1 AIRC PAIS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004638 | Phosphoribosylaminoimidazole carboxylase activity | TAS | molecular_function |
| GO:0004639 | Phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006189 | 'de novo' IMP biosynthetic process | IEA | biological_process |
| GO:0009113 | Purine nucleobase biosynthetic process | TAS | biological_process |
| GO:0009168 | Purine ribonucleoside monophosphate biosynthetic process | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9913681091 | 0.0026555602 | 0.9999902473 | 0.1024196193 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8458509657 |
| GSE13712_SHEAR | Up | 0.0031979577 |
| GSE13712_STATIC | Up | 0.3138985279 |
| GSE19018 | Up | 0.1919498080 |
| GSE19899_A1 | Down | -0.5831985116 |
| GSE19899_A2 | Down | -1.0560815360 |
| PubMed_21979375_A1 | Down | -0.6129350185 |
| PubMed_21979375_A2 | Down | -1.3662670485 |
| GSE35957 | Down | -0.6518125427 |
| GSE36640 | Down | -1.1362549975 |
| GSE54402 | Up | 0.1609097134 |
| GSE9593 | Down | -0.2950287026 |
| GSE43922 | Down | -0.5915729562 |
| GSE24585 | Down | -0.4595236434 |
| GSE37065 | Down | -0.2626470768 |
| GSE28863_A1 | Down | -0.4044555048 |
| GSE28863_A2 | Down | -0.2520362716 |
| GSE28863_A3 | Down | -0.3657007431 |
| GSE28863_A4 | Down | -0.0571693634 |
| GSE48662 | Down | -0.2990575146 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Aspartic Acid | DB00128 | NUTR00016 | EXPT01823 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028487 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT040996 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044654 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
