HCSGD entry for PRPF8
1. General information
| Official gene symbol | PRPF8 |
|---|---|
| Entrez ID | 10594 |
| Gene full name | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) |
| Other gene symbols | HPRP8 PRP8 PRPC8 RP13 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000375 | RNA splicing, via transesterification reactions | TAS | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | IC IEA TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005681 | Spliceosomal complex | IEA | cellular_component |
| GO:0005682 | U5 snRNP | TAS | cellular_component |
| GO:0006397 | MRNA processing | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0017070 | U6 snRNA binding | IEA | molecular_function |
| GO:0030623 | U5 snRNA binding | IEA | molecular_function |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5418024733 | 0.1750029558 | 0.9999902473 | 0.8093925145 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1700849261 |
| GSE13712_SHEAR | Down | -0.1481276069 |
| GSE13712_STATIC | Down | -0.0892058709 |
| GSE19018 | Down | -0.0664920907 |
| GSE19899_A1 | Down | -0.3145039425 |
| GSE19899_A2 | Down | -0.4346175287 |
| PubMed_21979375_A1 | Up | 0.3280383704 |
| PubMed_21979375_A2 | Up | 1.1159635640 |
| GSE35957 | Down | -0.4507106224 |
| GSE36640 | Down | -0.7074328265 |
| GSE54402 | Up | 0.0362202581 |
| GSE9593 | Down | -0.3138473351 |
| GSE43922 | Down | -0.0021211825 |
| GSE24585 | Down | -0.0968979005 |
| GSE37065 | Down | -0.3644374773 |
| GSE28863_A1 | Up | 0.5407961181 |
| GSE28863_A2 | Up | 0.1615846735 |
| GSE28863_A3 | Up | 0.0520410639 |
| GSE28863_A4 | Up | 0.0024541657 |
| GSE48662 | Up | 0.2334503076 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-532-3p | MIMAT0004780 | MIRT037930 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038451 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038822 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039792 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041232 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042093 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043237 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044089 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045253 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-140-5p | MIMAT0000431 | MIRT045825 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046232 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047439 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047660 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048232 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT048342 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048808 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049654 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050298 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050953 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051064 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051624 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051751 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052002 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
