HCSGD entry for SMC2
1. General information
| Official gene symbol | SMC2 |
|---|---|
| Entrez ID | 10592 |
| Gene full name | structural maintenance of chromosomes 2 |
| Other gene symbols | CAP-E CAPE SMC-2 SMC2L1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000228 | Nuclear chromosome | IDA | cellular_component |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000793 | Condensed chromosome | IDA | cellular_component |
| GO:0000796 | Condensin complex | IDA IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0007076 | Mitotic chromosome condensation | IDA IEA | biological_process |
| GO:0010032 | Meiotic chromosome condensation | IEA | biological_process |
| GO:0045132 | Meiotic chromosome segregation | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0051383 | Kinetochore organization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8665155427 | 0.0009963755 | 0.9999902473 | 0.0597394077 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5937166527 |
| GSE13712_SHEAR | Down | -0.3104754687 |
| GSE13712_STATIC | Down | -0.6914334248 |
| GSE19018 | Up | 0.5450575752 |
| GSE19899_A1 | Down | -0.7352304186 |
| GSE19899_A2 | Down | -2.1597797022 |
| PubMed_21979375_A1 | Down | -0.8985420562 |
| PubMed_21979375_A2 | Down | -2.4641352560 |
| GSE35957 | Down | -0.9243653222 |
| GSE36640 | Down | -2.7131666073 |
| GSE54402 | Down | -0.3206662197 |
| GSE9593 | Down | -0.6654291155 |
| GSE43922 | Down | -0.9782485227 |
| GSE24585 | Up | 0.2473566257 |
| GSE37065 | Down | -0.2250065768 |
| GSE28863_A1 | Down | -0.2777246463 |
| GSE28863_A2 | Up | 0.6791705462 |
| GSE28863_A3 | Down | -0.3259659645 |
| GSE28863_A4 | Up | 0.4079687201 |
| GSE48662 | Down | -0.6601277674 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024482 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026232 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046008 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
