HCSGD entry for NPC2

1. General information

Official gene symbolNPC2
Entrez ID10577
Gene full nameNiemann-Pick disease, type C2
Other gene symbolsEDDM1 HE1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005764LysosomeIDAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0009615Response to virusIEPbiological_process
GO:0015485Cholesterol bindingIDAmolecular_function
GO:0015914Phospholipid transportTASbiological_process
GO:0019747Regulation of isoprenoid metabolic processTASbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0030301Cholesterol transportIDAbiological_process
GO:0032366Intracellular sterol transportIDAbiological_process
GO:0032367Intracellular cholesterol transportIDA IGIbiological_process
GO:0033344Cholesterol effluxIDAbiological_process
GO:0042632Cholesterol homeostasisIDAbiological_process
GO:0046836Glycolipid transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01158191180.96781634820.27185575221.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.0485756480
GSE13712_SHEARDown-0.1786319980
GSE13712_STATICDown-0.0781117028
GSE19018Up0.6684649768
GSE19899_A1Up0.5234047175
GSE19899_A2Up0.1965298123
PubMed_21979375_A1Down-0.2678914906
PubMed_21979375_A2Up0.3083440517
GSE35957Down-0.1607092410
GSE36640Up0.9549249815
GSE54402Down-0.0735533688
GSE9593Up0.7807022137
GSE43922Up0.0018250063
GSE24585Up0.6424448949
GSE37065Up0.4793696309
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.2587698550

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92a-3pMIMAT0000092MIRT049322CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.