HCSGD entry for ARFGEF1


1. General information

Official gene symbolARFGEF1
Entrez ID10565
Gene full nameADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
Other gene symbolsARFGEP1 BIG1 P200
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIDAcellular_component
GO:0005085Guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0005086ARF guanyl-nucleotide exchange factor activityIBA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005802Trans-Golgi networkIBA ISScellular_component
GO:0005829CytosolIDAcellular_component
GO:0006887ExocytosisTASbiological_process
GO:0007030Golgi organizationIMPbiological_process
GO:0008060ARF GTPase activator activityIDAmolecular_function
GO:0010256Endomembrane system organizationIMPbiological_process
GO:0015031Protein transportIEAbiological_process
GO:0016192Vesicle-mediated transportIBAbiological_process
GO:0016363Nuclear matrixIEAcellular_component
GO:0017022Myosin bindingIPImolecular_function
GO:0030532Small nuclear ribonucleoprotein complexIDAcellular_component
GO:0030837Negative regulation of actin filament polymerizationIMPbiological_process
GO:0032012Regulation of ARF protein signal transductionIEAbiological_process
GO:0034237Protein kinase A regulatory subunit bindingIDAmolecular_function
GO:0034259Negative regulation of Rho GTPase activityIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0090284Positive regulation of protein glycosylation in GolgiIMPbiological_process
GO:0090303Positive regulation of wound healingIMPbiological_process
GO:2000114Regulation of establishment of cell polarityIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07858126210.91693503290.59099997151.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0038052588
GSE13712_SHEARUp0.1984359166
GSE13712_STATICUp0.0775117630
GSE19018Up0.2538691866
GSE19899_A1Down-0.0429903065
GSE19899_A2Up0.0456314579
PubMed_21979375_A1Up0.1575043935
PubMed_21979375_A2Up0.6623502570
GSE35957Up0.1795400684
GSE36640Up0.3052250558
GSE54402Down-0.1144892330
GSE9593Up0.3042248386
GSE43922Down-0.0309944815
GSE24585Up0.0597685445
GSE37065Up0.0736387505
GSE28863_A1Up0.7598569052
GSE28863_A2Up0.6267322251
GSE28863_A3Down-0.5856079194
GSE28863_A4Up0.0612491788
GSE48662Up0.0873021532

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024514MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026910MicroarrayFunctional MTI (Weak)19074876
hsa-miR-877-3pMIMAT0004950MIRT037025CLASHFunctional MTI (Weak)23622248
hsa-miR-125a-3pMIMAT0004602MIRT038638CLASHFunctional MTI (Weak)23622248
hsa-miR-10b-5pMIMAT0000254MIRT047437CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047646CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.