HCSGD entry for ARFGEF2

1. General information

Official gene symbolARFGEF2
Entrez ID10564
Gene full nameADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Other gene symbolsBIG2 PVNH2 dJ1164I10.1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIDAcellular_component
GO:0001881Receptor recyclingIDAbiological_process
GO:0005085Guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0005086ARF guanyl-nucleotide exchange factor activityIBA IDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005802Trans-Golgi networkIBA ISScellular_component
GO:0005815Microtubule organizing centerIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005879Axonemal microtubuleISScellular_component
GO:0006887ExocytosisIEAbiological_process
GO:0006893Golgi to plasma membrane transportIMPbiological_process
GO:0007032Endosome organizationIMPbiological_process
GO:0010256Endomembrane system organizationIMPbiological_process
GO:0015031Protein transportIEAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0016192Vesicle-mediated transportIBAbiological_process
GO:0017022Myosin bindingIEAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0031410Cytoplasmic vesicleISScellular_component
GO:0032012Regulation of ARF protein signal transductionIEAbiological_process
GO:0032279Asymmetric synapseISScellular_component
GO:0032280Symmetric synapseISScellular_component
GO:0032760Positive regulation of tumor necrosis factor productionIMPbiological_process
GO:0034237Protein kinase A regulatory subunit bindingIDAmolecular_function
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0043087Regulation of GTPase activityIBA IDAbiological_process
GO:0043197Dendritic spineISScellular_component
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050811GABA receptor bindingISSmolecular_function
GO:0055037Recycling endosomeIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01351566050.98322452790.29021965741.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1213952085
GSE13712_SHEARUp0.6780861505
GSE13712_STATICUp0.4675466956
GSE19018Up0.0443286164
GSE19899_A1Up0.2040694171
GSE19899_A2Up0.3944367379
PubMed_21979375_A1Up1.2854489921
PubMed_21979375_A2Up0.8821367153
GSE35957Up0.2629346467
GSE36640Up0.3191853866
GSE54402Up0.2653722201
GSE9593Up0.1354342731
GSE43922Up0.3029287577
GSE24585Up0.3424902929
GSE37065Up0.0307418619
GSE28863_A1Up0.3687129262
GSE28863_A2Up0.4257686176
GSE28863_A3Down-0.8134400103
GSE28863_A4Up0.0620936389
GSE48662Down-0.0697089644

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-766-3pMIMAT0003888MIRT039010CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042348CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050608CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.