HCSGD entry for SPTLC1
1. General information
| Official gene symbol | SPTLC1 |
|---|---|
| Entrez ID | 10558 |
| Gene full name | serine palmitoyltransferase, long chain base subunit 1 |
| Other gene symbols | HSAN HSAN1 HSN1 LBC1 LCB1 SPT1 SPTI hLCB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004758 | Serine C-palmitoyltransferase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006686 | Sphingomyelin biosynthetic process | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0017059 | Serine C-palmitoyltransferase complex | IDA | cellular_component |
| GO:0030148 | Sphingolipid biosynthetic process | TAS | biological_process |
| GO:0030170 | Pyridoxal phosphate binding | IEA | molecular_function |
| GO:0035339 | SPOTS complex | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046511 | Sphinganine biosynthetic process | IEA | biological_process |
| GO:0046512 | Sphingosine biosynthetic process | IEA | biological_process |
| GO:0046513 | Ceramide biosynthetic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1229691919 | 0.8652351354 | 0.7172898737 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2075140137 |
| GSE13712_SHEAR | Up | 0.1886057029 |
| GSE13712_STATIC | Up | 0.3274680093 |
| GSE19018 | Down | -0.3205239174 |
| GSE19899_A1 | Up | 0.0621782036 |
| GSE19899_A2 | Up | 0.3581685515 |
| PubMed_21979375_A1 | Up | 1.4497661887 |
| PubMed_21979375_A2 | Up | 0.4454866846 |
| GSE35957 | Down | -0.1758309375 |
| GSE36640 | Up | 0.4519840202 |
| GSE54402 | Down | -0.1053771019 |
| GSE9593 | Up | 0.2257265014 |
| GSE43922 | Up | 0.1414640242 |
| GSE24585 | Up | 0.1095984084 |
| GSE37065 | Down | -0.0032351328 |
| GSE28863_A1 | Down | -0.0471208958 |
| GSE28863_A2 | Down | -0.1598654673 |
| GSE28863_A3 | Down | -0.3780409425 |
| GSE28863_A4 | Up | 0.2176375649 |
| GSE48662 | Down | -0.3739430960 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001411 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-374b-5p | MIMAT0004955 | MIRT016036 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023301 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045166 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049097 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
