HCSGD entry for DCTN2
1. General information
| Official gene symbol | DCTN2 |
|---|---|
| Entrez ID | 10540 |
| Gene full name | dynactin 2 (p50) |
| Other gene symbols | DCTN50 DYNAMITIN RBP50 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0003774 | Motor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005869 | Dynactin complex | IDA IEA | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0007017 | Microtubule-based process | IEA | biological_process |
| GO:0007052 | Mitotic spindle organization | IEA | biological_process |
| GO:0007067 | Mitosis | IEA IMP | biological_process |
| GO:0008283 | Cell proliferation | IMP | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0030286 | Dynein complex | IEA | cellular_component |
| GO:0030426 | Growth cone | IEA | cellular_component |
| GO:0031982 | Vesicle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9259761787 | 0.1961703811 | 0.9999902473 | 0.8577077409 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0213180284 |
| GSE13712_SHEAR | Down | -0.2916641784 |
| GSE13712_STATIC | Up | 0.0433646781 |
| GSE19018 | Up | 0.1165559579 |
| GSE19899_A1 | Down | -0.0853511563 |
| GSE19899_A2 | Up | 0.2703140362 |
| PubMed_21979375_A1 | Up | 0.0004533802 |
| PubMed_21979375_A2 | Down | -0.1261771663 |
| GSE35957 | Up | 0.0258283964 |
| GSE36640 | Up | 0.2492411414 |
| GSE54402 | Up | 0.0851642366 |
| GSE9593 | Up | 0.0877730810 |
| GSE43922 | Down | -0.1047479049 |
| GSE24585 | Down | -0.0149442581 |
| GSE37065 | Down | -0.1719729880 |
| GSE28863_A1 | Down | -0.3889179867 |
| GSE28863_A2 | Down | -0.2745079674 |
| GSE28863_A3 | Down | -0.2108763850 |
| GSE28863_A4 | Down | -0.2513934466 |
| GSE48662 | Up | 0.0099858576 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-502-3p | MIMAT0004775 | MIRT037985 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045677 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050704 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
