HCSGD entry for ATG7

1. General information

Official gene symbolATG7
Entrez ID10533
Gene full nameautophagy related 7
Other gene symbolsAPG7-LIKE APG7L GSA7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000407Pre-autophagosomal structureIEAcellular_component
GO:0001889Liver developmentIEAbiological_process
GO:0004839Ubiquitin activating enzyme activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005930AxonemeISScellular_component
GO:0006464Cellular protein modification processTASbiological_process
GO:0006497Protein lipidationIDAbiological_process
GO:0006520Cellular amino acid metabolic processIEAbiological_process
GO:0006914AutophagyIEAbiological_process
GO:0006996Organelle organizationIEAbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0015031Protein transportIEAbiological_process
GO:0016239Positive regulation of macroautophagyIMPbiological_process
GO:0019778APG12 activating enzyme activityIEA ISSmolecular_function
GO:0021680Cerebellar Purkinje cell layer developmentIEAbiological_process
GO:0021860Pyramidal neuron developmentIEAbiological_process
GO:0021955Central nervous system neuron axonogenesisIEAbiological_process
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0030163Protein catabolic processIEAbiological_process
GO:0031396Regulation of protein ubiquitinationIEAbiological_process
GO:0031401Positive regulation of protein modification processIDA IEAbiological_process
GO:0032446Protein modification by small protein conjugationIEAbiological_process
GO:0042594Response to starvationIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0050877Neurological system processIEAbiological_process
GO:0055013Cardiac muscle cell developmentIEAbiological_process
GO:0061025Membrane fusionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06176075380.78711351010.53845803251.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3090149901
GSE13712_SHEARDown-0.2493115172
GSE13712_STATICDown-0.0802874537
GSE19018Up0.2037795797
GSE19899_A1Up0.1555979431
GSE19899_A2Up0.8926128687
PubMed_21979375_A1Up0.7547709926
PubMed_21979375_A2Up1.0381181125
GSE35957Up0.1284044260
GSE36640Down-0.0100795650
GSE54402Up0.6781510046
GSE9593Up0.1226693108
GSE43922Up0.4014907634
GSE24585Down-0.0022796604
GSE37065Up0.0015265220
GSE28863_A1Up0.0684355337
GSE28863_A2Down-0.2161704980
GSE28863_A3Down-0.9161959275
GSE28863_A4Down-0.1969617287
GSE48662Up0.0255338971

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT020034MicroarrayFunctional MTI (Weak)20215506
hsa-miR-320cMIMAT0005793MIRT036161CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26391655Tissue-specific deletion of the essential autophagy gene Atg7 in murine VSMCs (atg7-/- VSMCs) caused accumulation of SQSTM1/p62 and accelerated the development of stress-induced premature senescence as shown by cellular and nuclear hypertrophy, CDKN2A-RB-mediated G1 proliferative arrest and senescence-associated GLB1 activity
26391655Transfection of SQSTM1-encoding plasmid DNA in Atg7+/+ VSMCs induced similar features, suggesting that accumulation of SQSTM1 promotes VSMC senescence
26159917Additionally, the cellular senescence phenotypes were manifested at the molecular level by a significant increase in p21 and p53 expression, a decrease in SOD2 expression, and a decrease in expression of some key autophagy-related genes such as Atg5, Atg7, Atg12, and Beclin 1
25413053METHODS: BJ cells were transfected with H-RasV12 or control vector and treated with chloroquine, small interfering RNA (siRNA) for ATG7, or rapamycin
25413053Rapamycin treatment and siRNA suppression of ATG7 had no obvious effect on control BJ cells
25341032The role of autophagy-related 5 (ATG5)-dependent autophagy in regulating the tempo, duration and magnitude of cellular stress responses in vivo was corroborated by in vitro studies using MEFs lacking ATG5 or autophagy-related 7 (ATG7) and autophagy inhibitors
25310478During MSC senescence, the levels of autophagic activity were increased, a greater number of autophagic vacuoles were observed in senescent MSCs by transmission electron microscopy, acridine orange staining was elevated and the expression levels of autophagyrelated proteins (microtubuleassociated protein 1A/1Blight chain 3-II, Atg7 and Atg12) were increased
22898871The inhibition of autophagy by silencing the expression of the proteins ATG7 or Beclin-1 prevents the increase of SA-beta-Gal staining in response to imatinib plus Z-Vad
21858089METHODOLOGY/PRINCIPAL FINDINGS: Depletion of ATG7, ATG12, or lysosomal-associated membrane protein 2 (Lamp2) by transfecting siRNA or infecting cells with a virus containing gene-specific shRNA resulted in a senescence-like state in two strains of primary human fibroblasts
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