HCSGD entry for PITRM1
1. General information
| Official gene symbol | PITRM1 |
|---|---|
| Entrez ID | 10531 |
| Gene full name | pitrilysin metallopeptidase 1 |
| Other gene symbols | MP1 PreP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004222 | Metalloendopeptidase activity | IMP | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA IMP | biological_process |
| GO:0008047 | Enzyme activator activity | TAS | molecular_function |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3340788914 | 0.8293252118 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2414974581 |
| GSE13712_SHEAR | Up | 0.3273485263 |
| GSE13712_STATIC | Up | 0.3829956662 |
| GSE19018 | Up | 0.1619735926 |
| GSE19899_A1 | Down | -0.2009717745 |
| GSE19899_A2 | Down | -0.0384527189 |
| PubMed_21979375_A1 | Down | -0.4647625540 |
| PubMed_21979375_A2 | Down | -0.0260484969 |
| GSE35957 | Up | 0.0351126003 |
| GSE36640 | Down | -0.0782932532 |
| GSE54402 | Up | 0.2153136461 |
| GSE9593 | Up | 0.1429871083 |
| GSE43922 | Down | -0.0246466986 |
| GSE24585 | Down | -0.1990220881 |
| GSE37065 | Up | 0.0203624813 |
| GSE28863_A1 | Up | 0.2564627836 |
| GSE28863_A2 | Up | 0.1902909176 |
| GSE28863_A3 | Up | 0.0971034676 |
| GSE28863_A4 | Up | 0.1443963301 |
| GSE48662 | Down | -0.1303543518 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1303 | MIMAT0005891 | MIRT035886 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-502-3p | MIMAT0004775 | MIRT037980 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038903 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041475 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049603 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11900490 | We herein report that PUVA-induced growth arrest, the senescent phenotype with long-term induction of senescence-associated beta-galactosidase, as well as increased expression of matrix metalloprotease-1 are fully reversible at days 100 to 130 post PUVA treatment in four independently tested fibroblast strains |
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