HCSGD entry for KAT5

1. General information

Official gene symbolKAT5
Entrez ID10524
Gene full nameK(lysine) acetyltransferase 5
Other gene symbolsESA1 HTATIP HTATIP1 PLIP TIP TIP60 ZC2HC5 cPLA2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0000785ChromatinIEAcellular_component
GO:0003713Transcription coactivator activityIDA TASmolecular_function
GO:0004402Histone acetyltransferase activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006302Double-strand break repairIMPbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIDAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0010212Response to ionizing radiationIDAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016573Histone acetylationIDA IEAbiological_process
GO:0016747Transferase activity, transferring acyl groups other than amino-acyl groupsIEAmolecular_function
GO:0030521Androgen receptor signaling pathwayNASbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032703Negative regulation of interleukin-2 productionIDAbiological_process
GO:0032777Piccolo NuA4 histone acetyltransferase complexIDAcellular_component
GO:0035267NuA4 histone acetyltransferase complexIDAcellular_component
GO:0040008Regulation of growthIEAbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA NASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050681Androgen receptor bindingNASmolecular_function
GO:0070491Repressing transcription factor bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96738274380.11079754570.99999024730.6376340621

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1067339580
GSE13712_SHEARDown-0.0312873214
GSE13712_STATICDown-0.2140912165
GSE19018Down-0.1818064683
GSE19899_A1Down-0.3323655167
GSE19899_A2Down-0.5551557073
PubMed_21979375_A1Down-0.1682048536
PubMed_21979375_A2Down-0.1730573187
GSE35957Down-0.0787265494
GSE36640Down-0.3238390641
GSE54402Up0.0998774346
GSE9593Up0.0704397836
GSE43922Down-0.0916876658
GSE24585Down-0.1208653810
GSE37065Up0.1981028431
GSE28863_A1Up0.0043414286
GSE28863_A2Down-0.1499139272
GSE28863_A3Down-0.4969419488
GSE28863_A4Down-0.0451358470
GSE48662Down-0.0011280388

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1215739CHEMBL57509Q92993
CHEMBL455368CHEMBL57509Q92993
CHEMBL455368CHEMBL57509Q92993
CHEMBL1213327CHEMBL57508Q92993
CHEMBL505121CHEMBL57508Q92993
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  • Drugs

Name

Drug

Accession number

Coenzyme ADB01992 EXPT00991
S-Acetyl-CysteineDB02039 EXPT02873

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-766-3pMIMAT0003888MIRT039033CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21555914We recently identified a signaling network involving the acetyltransferase TIP60, the deacetylase HDAC6 and the SRPK kinases that regulates SRSF2 protein turnover through phosphorylation/acetylation modifications in response to cisplatin
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