HCSGD entry for MYBBP1A
1. General information
| Official gene symbol | MYBBP1A |
|---|---|
| Entrez ID | 10514 |
| Gene full name | MYB binding protein (P160) 1a |
| Other gene symbols | P160 PAP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA ISS | cellular_component |
| GO:0005730 | Nucleolus | IDA ISS | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0006913 | Nucleocytoplasmic transport | ISS | biological_process |
| GO:0008134 | Transcription factor binding | TAS | molecular_function |
| GO:0022904 | Respiratory electron transport chain | IEA | biological_process |
| GO:0042149 | Cellular response to glucose starvation | IDA | biological_process |
| GO:0042564 | NLS-dependent protein nuclear import complex | ISS | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0071158 | Positive regulation of cell cycle arrest | IMP | biological_process |
| GO:0072332 | Intrinsic apoptotic signaling pathway by p53 class mediator | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0207678052 | 0.6406431709 | 0.3468460660 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3565495302 |
| GSE13712_SHEAR | Up | 0.4484291511 |
| GSE13712_STATIC | Up | 0.2985628899 |
| GSE19018 | Down | -0.3952834770 |
| GSE19899_A1 | Up | 0.2679298098 |
| GSE19899_A2 | Up | 0.5946316706 |
| PubMed_21979375_A1 | Up | 1.4026796011 |
| PubMed_21979375_A2 | Up | 0.8863251927 |
| GSE35957 | Down | -0.1233979295 |
| GSE36640 | Up | 0.0362918962 |
| GSE54402 | Up | 0.5557660939 |
| GSE9593 | Down | -0.3505138145 |
| GSE43922 | Up | 0.5401578383 |
| GSE24585 | Down | -1.2295059704 |
| GSE37065 | Down | -0.1856447358 |
| GSE28863_A1 | Up | 0.2271607204 |
| GSE28863_A2 | Up | 0.2272419794 |
| GSE28863_A3 | Up | 0.2076912596 |
| GSE28863_A4 | Up | 0.0757841506 |
| GSE48662 | Down | -0.1123815295 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027438 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029101 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-30b-3p | MIMAT0004589 | MIRT038652 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041453 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043518 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047122 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049640 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25543088 | Myb-binding protein 1A (MYBBP1A) is a nucleolar protein implicated in stress response and carcinogenesis; however, its functional contribution to senescence remains elusive |
| 25543088 | In this study we show decreased MYBBP1A protein levels in tumor cells after treatment with etoposide, a potent inducer of DNA damage |
| 25543088 | Although silencing of MYBBP1A expression was not sufficient to induce senescence, it significantly increased the relative abundance of senescent cells after DNA damage |
| 25543088 | We found an inverse regulation of MYBBP1A and AKT phosphorylation (pAKT(Ser473)), which was characteristic for the pre-senescent state after etoposide administration in vitro |
| 25543088 | Taken together, our study points to a critical role of MYBBP1A in the regulation of senescence under genotoxic stress and that a MYBBP1A(low)AKT(Ser473)(high) staining pattern serves not only as a marker for the pre-senescent stage but also as an indicator of OPSCC patients at high risk for treatment failure |
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